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S8753

Strychnine hydrochloride

glycine receptor antagonist

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About This Item

Empirical Formula (Hill Notation):
C21H22N2O2 · HCl
CAS Number:
1421-86-9
Molecular Weight:
370.87
NACRES:
NA.32
PubChem Substance ID:
24899812
UNSPSC Code:
12352210
EC Number:
215-826-9
MDL number:
MFCD00058174
Quality level:
100
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Product Name

Strychnine hydrochloride,

Quality Level

100

SMILES string

Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1

InChI key

VLXYTKMPCOQKEM-ZEYGOCRCSA-N

Related Categories

Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Biochem/physiol Actions

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
Convulsant; glycine receptor antagonist not associated with the NMDA receptor.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ5918
MKCN1074
MKCN0910
MKCH3395
MKCF3765

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Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
Bhati R, et al.
Journal of Ayurveda and integrative medicine, 3(2), 80-80 (2012)
Horizontal cell feedback without cone type-selective inhibition mediates red?green color opponency in midget ganglion cells of the primate retina
Crook JD, et al.
The Journal of Neuroscience, 31(5), 1762-1772 (2011)
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina
Crook JD, et al.
The Journal of Neuroscience, 28(44), 11277-11291 (2008)
Daniel S Borrus et al.
eNeuro, 7(3) (2020-05-13)
The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms. We measured breathing in awake intact adult mice and recorded
Effect of Strychinine, a Glycine Inhibitor, on the Programmed Cell Death of Motoneurons during the Chick Development.
Kim JY
Experimental Neurobiology, 20(4), 176-180 (2011)
View All Related Papers

Related Content

Product Information Sheet - S8753

Product Information Sheet

Global Trade Item Number

SKUGTIN
S8753-25G04061836961022
S8753-5G04061832274171
S8753-100G04061832286662

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