SAB3500566
Anti-TCF12 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-HEB, Anti-HTF4, Anti-bHLHb20
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), ICC, WB
Citations:
9
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse, rat
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TCF12(6938)
General description
Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3.
Immunogen
TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12.
Application
Anti-TCF12 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500566.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Expression of the bHLH transcription factor Tcf12 (ME1) gene is linked to the expansion of precursor cell populations during neurogenesis
Uittenbogaard M and Chiaramello A
Gene Expression Patterns, 1(2), 115-121 (2002)
TCF12 is mutated in anaplastic oligodendroglioma
Labreche K, et al.
Nature Communications, 6(3), 7207-7207 (2015)
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+ CD8+ thymocytes
Emmanuel AO, et al.
Nature Immunology, 6(3), 1-1 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SBP3500566-0.05MG | 04061832170459 |
| SAB3500566-100UG | 04061835709052 |