SML0010
LY-334370 hydrochloride hydrate
≥98% (HPLC), powder
Synonym(s):
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
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About This Item
Empirical Formula (Hill Notation):
C21H22FN3O · HCl · xH2O
CAS Number:
Molecular Weight:
387.88 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
InChI key
DGPDGAPZTPSHBL-UHFFFAOYSA-N
SMILES string
Cl.CN1CCC(CC1)c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23
InChI
1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
H2O: ≥5 mg/mL (warmed)
originator
Eli Lilly
storage temp.
2-8°C
Application
LY-334370 hydrochloride hydrate may be used to study 5-HT 1F-mediated cell signaling.
Biochem/physiol Actions
LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.
LY-334370 modulates the transmission in the mouse trigeminal system and inhibits the neuronal responses within rat Sp5C by inhibiting c-Fos activation. It shows efficacy in aborting migraine attacks.
Features and Benefits
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Sandra A Filla et al.
Journal of medicinal chemistry, 46(14), 3060-3071 (2003-06-27)
Compound 1a (LY334370), a selective 5-HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of migraine and demonstrated clinical efficacy for the acute treatment of migraine. Although 1a was greater than 100-fold selective over both
D D Mitsikostas et al.
Cephalalgia : an international journal of headache, 22(5), 384-394 (2002-07-12)
In order to investigate the c-fos response within the trigeminal nucleus caudalis (Sp5C) after noxious meningeal stimulation, capsaicin (0.25, 0.5, 1 and 5 nmol) was administered intracisternally in urethane (1 g/kg) and alpha-chloralose (20 mg/kg) anaesthetized male mice. Capsaicin induced
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