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T1505

Tetraisopropyl pyrophosphoramide

Name: Tetraisopropyl pyrophosphoramide
Brand: SIGMA

butyrylcholinesterase inhibitor

Synonym(s):

Tetra(monoisopropyl)pyrophosphortetramide, iso-OMPA

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₃₂N₄O₃P₂

CAS Number:

513-00-8

Molecular Weight:

342.36

NACRES:

NA.77

PubChem Substance ID:

24278724

UNSPSC Code:

12352202

EC Number:

208-149-5

MDL number:

MFCD00048272

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Properties

biological source

synthetic

mp

149-151 °C

storage temp.

−20°C

SMILES string

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI key

IOIMDJXKIMCMIG-UHFFFAOYSA-N

Gene Information

human ... ACHE(43), BCHE(590)

Description

Application

Tetraisopropyl pyrophosphoramide has been used:

as a butyrylcholinesterase inhibitor to determine the proportions of butyrylcholinesterase (BChE) in cat and tiger plasma
to inhibit wild-type BChE in acetylcholinesterase assay
to selectively block the enzymatic activity of AChE

Biochem/physiol Actions

Selective inhibitor of butyrylcholinesterase

Disclaimer

WARNING: Extremely hazardous! Be aware of the risk and familiar with safety procedures before you use this product.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.

Bartels CF, et al.

Biochemical Pharmacology, 60(4), 479-487 (2018)

Postnatal development of nitrergic and cholinergic structures in rat spinal cord

Bolekova A, et al.

Archives Italiennes de Biologie, 149(3), 293-302 (2011)

Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Liyi Geng et al.

PloS one, 8(6), e67446-e67446 (2013-07-11)

Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a

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Global Trade Item Number

SKU	GTIN
T1505-1G	04061826745823
T1505-250MG	04061837337642
T1505-100MG	04061837337635