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T1505

Tetraisopropyl pyrophosphoramide

Name: Tetraisopropyl pyrophosphoramide
Brand: SIGMA

butyrylcholinesterase inhibitor

Synonym(s):

Tetra(monoisopropyl)pyrophosphortetramide, iso-OMPA

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₃₂N₄O₃P₂

CAS Number:

513-00-8

Molecular Weight:

342.36

NACRES:

NA.77

PubChem Substance ID:

24278724

UNSPSC Code:

12352202

EC Number:

208-149-5

MDL number:

MFCD00048272

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biological source

synthetic

mp

149-151 °C

storage temp.

−20°C

SMILES string

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI key

IOIMDJXKIMCMIG-UHFFFAOYSA-N

Gene Information

human ... ACHE(43), BCHE(590)

Application

Tetraisopropyl pyrophosphoramide has been used:

as a butyrylcholinesterase inhibitor to determine the proportions of butyrylcholinesterase (BChE) in cat and tiger plasma
to inhibit wild-type BChE in acetylcholinesterase assay
to selectively block the enzymatic activity of AChE

Biochem/physiol Actions

Selective inhibitor of butyrylcholinesterase

Disclaimer

WARNING: Extremely hazardous! Be aware of the risk and familiar with safety procedures before you use this product.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Postnatal development of nitrergic and cholinergic structures in rat spinal cord

Bolekova A, et al.

Archives Italiennes de Biologie, 149(3), 293-302 (2011)

Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.

Bartels CF, et al.

Biochemical Pharmacology, 60(4), 479-487 (2018)

Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity.

Liyi Geng et al.

PloS one, 8(6), e67446-e67446 (2013-07-11)

Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase

Wang YW, et al.

Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)

The impact of damage-associated molecular patterns on the neurotransmitter release and gene expression in the ex vivo rat carotid body.

Souren Mkrtchian et al.

Experimental physiology, 105(9), 1634-1647 (2020-07-12)

What is the central question of this study? Are carotid bodies (CBs) modulated by the damage-associated molecular patterns (DAMPs) and humoral factors of aseptic tissue injury? What are the main findings and their importance? DAMPs (HMGB1, S100 A8/A9) and blood

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Global Trade Item Number

SKU	GTIN
T1505-1G	04061826745823
T1505-250MG	04061837337642
T1505-100MG	04061837337635

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