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T6140

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt

Name: N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt
Brand: SIGMA

plasmin substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

N-Tosylglycyl-L-prolyl-L-lysine 4-nitroanilide acetate salt

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About This Item

Linear Formula:

C₂₆H₃₄N₆O₇S · C₂H₄O₂

CAS Number:

88793-79-7

Molecular Weight:

634.70

NACRES:

NA.32

PubChem Substance ID:

24900352

UNSPSC Code:

12352204

EC Number:

289-446-7

MDL number:

MFCD00057232

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Product Name

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt, plasmin substrate

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, colorless to yellow

storage temp.

−20°C

SMILES string

CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)Nc3ccc(cc3)[N+]([O-])=O

InChI

1S/C26H34N6O7S.C2H4O2/c1-18-7-13-21(14-8-18)40(38,39)28-17-24(33)31-16-4-6-23(31)26(35)30-22(5-2-3-15-27)25(34)29-19-9-11-20(12-10-19)32(36)37;1-2(3)4/h7-14,22-23,28H,2-6,15-17,27H2,1H3,(H,29,34)(H,30,35);1H3,(H,3,4)/t22-,23-;/m0./s1

InChI key

KPGSNEYSJPIZCW-SJEIDVEUSA-N

General description

A chromogenic substrate for plasmin.

Application

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt has been used:

as a substrate for examining the amidolytic activity of aprE2, aprE5-41
as a substrate for serine protease and fibrinogenolytic assays
as a substrate for plasmin assay

Biochem/physiol Actions

N-(p-Tosyl)-Gly-Pro-Lys 4-nitroanilide acetate salt is a chromogenic substrate for plasmin assay, serine protease enzyme activity and fibrinogenolytic assays.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.

Attali C, et al.

Infection and Immunity, 76(2), 466-476 (2008)

Overexpression of aprE2, a Fibrinolytic Enzyme Gene from Bacillus subtilis CH3-5, in Escherichia coli and the Properties of AprE2.

Jeong SJ, et al.

Journal of microbiology and biotechnology, 24(7), 969-978 (2014)

Construction of a novel Staphylokinase (SAK) mutant with low immunogenicity and its evaluation in rhesus monkey.

Min Wang et al.

International journal of biological macromolecules, 146, 781-789 (2019-11-16)

The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow

A bi-functional anti-thrombosis protein containing both direct-acting fibrin (ogen) olytic and plasminogen-activating activities

Yang H, et al.

PLoS ONE, 6(3), e17519-e17519 (2011)

PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.

Michał Śmiga et al.

BMC microbiology, 19(1), 127-127 (2019-06-13)

Porphyromonas gingivalis is considered a keystone pathogen responsible for chronic periodontitis. Although several virulence factors produced by this bacterium are quite well characterized, very little is known about regulatory mechanisms that allow different strains of P. gingivalis to efficiently survive

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Global Trade Item Number

SKU	GTIN
T6140-25MG	04061832918594
T6140-5MG	04061837358401
T6140-10MG	04061832918587

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