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Merck
CN

A0216

N-Acetyl-Trp-Glu-His-Asp-7-amido-4-methylcoumarin

≥97% (HPLC), powder

Synonym(s):

Ac-WEHD-AMC

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About This Item

Empirical Formula (Hill Notation):
C38H40N8O11
Molecular Weight:
784.77
UNSPSC Code:
12352200
MDL number:
MFCD01318829

Key Documents

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Product Name

N-Acetyl-Trp-Glu-His-Asp-7-amido-4-methylcoumarin, ≥97% (HPLC), powder

InChI key

NONBZTYCHSGHGG-KRCBVYEFSA-N

InChI

1S/C38H40N8O11/c1-19-11-34(52)57-31-14-22(7-8-24(19)31)43-36(54)30(15-33(50)51)46-38(56)29(13-23-17-39-18-41-23)45-35(53)27(9-10-32(48)49)44-37(55)28(42-20(2)47)12-21-16-40-26-6-4-3-5-25(21)26/h3-8,11,14,16-18,27-30,40H,9-10,12-13,15H2,1-2H3,(H,39,41)(H,42,47)(H,43,54)(H,44,55)(H,45,53)(H,46,56)(H,48,49)(H,50,51)/t27-,28-,29-,30-/m0/s1

SMILES string

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(O)=O)C(=O)Nc4ccc5C(C)=CC(=O)Oc5c4

assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

Gene Information

human ... CASP1(834)
mouse ... CASP1(12362)
rat ... CASP1(25166)

Biochem/physiol Actions

Fluorogenic substrate for caspase 1.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
098H1191

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Lakshmi Galam et al.
American journal of physiology. Lung cellular and molecular physiology, 310(6), L572-L581 (2016-01-10)
Increasing evidence shows that hyperoxia is a serious complication of oxygen therapy in acutely ill patients that causes excessive production of free radicals leading to hyperoxia-induced acute lung injury (HALI). Our previous studies have shown that P2X7 receptor activation is
T A Rano et al.
Chemistry & biology, 4(2), 149-155 (1997-02-01)
Interleukin-1beta converting enzyme (ICE/caspase-1) is the protease responsible for interleukin-1beta (IL-1beta) production in monocytes. It was the first member of a new cysteine protease family to be identified. Members of this family have functions in both inflammation and apoptosis. A

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