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Merck
CN

A0401

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

Synonym(s):

ACTH4-10

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About This Item

Empirical Formula (Hill Notation):
C44H59N13O10S
CAS Number:
4037-01-8
Molecular Weight:
962.09
MDL number:
MFCD00167482
UNSPSC Code:
12352202
PubChem Substance ID:
24890423
NACRES:
NA.26

Key Documents

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Product Name

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

Assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189
P47866

storage temp.

−20°C

SMILES string

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Crhr2(64680)

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Lacks adrenocorticotropic activity.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBR4975V
BCBH4677V
BCBB5783V
BCBB5783
BCBB0110

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Bela Juhasz et al.
Antioxidants & redox signaling, 9(11), 1851-1861 (2007-08-25)
The aim of our study was to investigate the contribution of the adrenocorticotropic hormone fragment, ACTH (4-10), on the recovery of postischemic cardiac function. Effects of ACTH (4-10) on caspase-3 activity, cardiomyocyte and endothelial apoptosis, and HO-1 protein expression were
Kun Wang et al.
International immunopharmacology, 87, 106769-106769 (2020-07-19)
In the present study, we aimed to assess whether adrenocorticotropic hormone (ACTH) could protect the podocytes from adriamycin (ADR)-induced injury by stimulating B lymphocytes to secrete the associated cytokines. Proliferation assay was used to assess the proliferation and activity of
Manfred Hallschmid et al.
The Journal of clinical endocrinology and metabolism, 91(2), 522-525 (2005-12-01)
By enhancing energy expenditure and suppressing appetite, melanocortin peptides derived from proopiomelanocortin play a primary role in the hypothalamic regulation of body weight. In a recent study in normal-weight adults, the 6-wk intranasal administration of the MSH/ACTH(4-10) core fragment of
Heiko Krude et al.
The Journal of clinical endocrinology and metabolism, 88(10), 4633-4640 (2003-10-15)
The symptoms of severe early-onset obesity, adrenal insufficiency, and red hair define the proopiomelanocortin (POMC) deficiency syndrome as described so far in two children with complete loss-of-function mutations of the human POMC gene. In POMC deficiency, obesity reflects the lack
The active sequence in the ACTH molecule responsible for inhibition of the extinction of conditioned avoidance behaviour in rats.
H M Greven et al.
European journal of pharmacology, 2(1), 14-16 (1967-10-01)
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