A0479
Adrafinil
≥98% (HPLC), solid
Synonym(s):
2-[(Diphenylmethyl)sulfinyl]acetohydroxamic acid, CRL 40028, Olmifon
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About This Item
Empirical Formula (Hill Notation):
C15H15NO3S
CAS Number:
Molecular Weight:
289.35
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
264-303-1
MDL number:
InChI key
CGNMLOKEMNBUAI-UHFFFAOYSA-N
InChI
1S/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15,18H,11H2,(H,16,17)
SMILES string
ONC(=O)CS(=O)C(c1ccccc1)c2ccccc2
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
DMSO: 35 mg/mL
Biochem/physiol Actions
Agent promoting wakefulness; analog of Modafinil.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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C L Milhaud et al.
Journal de pharmacologie, 16(4), 372-380 (1985-10-01)
The nocturnal activity of a primate was used as an evaluation criterium for a stimulating substance: adrafinil (CRL 40028). Ten rhesus monkeys were placed in a controlled environment and their activity was measured, in relative time, using an ultra-sound system.
Jianghai Lu et al.
Rapid communications in mass spectrometry : RCM, 23(11), 1592-1600 (2009-04-29)
A new and reliable two-step liquid chromatography/tandem mass spectrometry (LC/MS/MS) method in combination with gas chromatography/mass spectrometry (GC/MS) for the screening and confirmation of adrafinil and its major metabolites, modafinil and modafinil acid, in human urine has been developed and
Christina T Siwak et al.
Pharmacology, biochemistry, and behavior, 76(1), 161-168 (2003-09-19)
Previous studies in humans and dogs have reported beneficial effects of adrafinil on specific cognitive functions. The effects in dogs are limited to a single study examining discrimination learning. We wanted to further explore the cognitive effects of adrafinil in
C T Siwak et al.
Progress in neuro-psychopharmacology & biological psychiatry, 24(5), 709-726 (2001-02-24)
1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting
C T Siwak et al.
American journal of veterinary research, 61(11), 1410-1414 (2000-12-07)
To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. 36 Beagles between 9 and 16 years old. Dogs were randomly assigned to receive adrafinil (20 mg/kg of body weight, PO, q 24 h; n
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