A0601
Activin Receptor-Like Kinase 1/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in NSO cells
Assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
20-80 ng/mL ED50
mol wt
50-55 kDa by SDS-PAGE (reducing)
calculated mol wt ~37.7 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Acvrl1(11482)
Biochem/physiol Actions
ALK-1 is a type I complex of the serine/threonine kinases. Type I and II receptors bind ligands in the TGF-β superfamily. Human and mouse ALK-1 share approximately 71% amino acid sequence identity in their extracellular domains.
Type I complex of the serine/threonine kinases; bind ligands in the TGF-β superfamily.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
Can be used as a calibrator for ALK-1 antibodies.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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A Lux et al.
The Journal of biological chemistry, 274(15), 9984-9992 (1999-04-03)
Germ line mutations in one of two distinct genes, endoglin or ALK-1, cause hereditary hemorrhagic telangiectasia (HHT), an autosomal dominant disorder of localized angiodysplasia. Both genes encode endothelial cell receptors for the transforming growth factor beta (TGF-beta) ligand superfamily. Endoglin
P ten Dijke et al.
Oncogene, 8(10), 2879-2887 (1993-10-01)
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity
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