A0699
Activin Receptor IA human
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
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About This Item
UNSPSC Code:
51111800
MDL number:
Biochem/physiol Actions
Activin receptor IA/Fc chimera does not bind directly to activin or inhibin but will associate with the type II receptor-activin complex and initiate signal transduction. Activin isoforms are members of the TGF-β superfamily that bind to heteromeric complexes of type I and type II serine/threonine kinase receptors, both of which are essential for signal transduction. Human, murine, and bovine type IA activin receptors demonstrate greater than 98% homology.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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L Attisano et al.
Molecular and cellular biology, 16(3), 1066-1073 (1996-03-01)
Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are
Yong-Gil Kim et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2793-2803 (2014-07-02)
Although ankylosing spondylitis (AS) is driven by immune-mediated processes, little is known about the presence and role of autoantibodies in this disease. This study was undertaken to investigate whether autoantibodies occur in and are involved in AS. We performed human
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