A0844
Anti-AP-2α antibody produced in rabbit
affinity isolated antibody, PBS solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
PBS solution
mol wt
antigen ~50 kDa
species reactivity
mouse, human, chicken
technique(s)
indirect immunofluorescence: 1:100 using cultured human HeLa cells
microarray: suitable
western blot: 1:250 using a nuclear extract from HeLa human carcinoma cells
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TFAP2A(7020)
General description
Activation Protein transcription factor 2 (AP-2) is a developmentally modulated transcription factor that binds to specific sequence such as CCCCAGGC or related sequences. These sequences are usually present in several promoter and enhancer gene regions, including the promoters of the AP-2 genes themselves,,. AP-2 expression has also been linked to human breast cancer cells.
By immunoblotting, rabbit anti-AP-2α reacts specifically with human AP-2α. The sequence recognized by the antibody differs from the corresponding mouse sequence by one residue and from the chicken sequence by 2 residues.
By immunoblotting, rabbit anti-AP-2α reacts specifically with human AP-2α. The sequence recognized by the antibody differs from the corresponding mouse sequence by one residue and from the chicken sequence by 2 residues.
Immunogen
synthetic peptide corresponding to human AP-2α, C-terminal sequence, (amino acids 420-437) conjugated to KLH with glutaraldehyde.
Application
Rabbit anti-AP-2alpha antibody can be used for western blot (1:250), microarray and indirect immunofluorescence (1:100) assays.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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B C Turner et al.
Cancer research, 58(23), 5466-5472 (1998-12-16)
The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated that the AP-2 family of proteins may be involved in the etiology of human breast cancer. The AP-2 genes
N Mohibullah et al.
Nucleic acids research, 27(13), 2760-2769 (1999-06-22)
The AP-2 family of transcription factors are defined by the presence of a novel DNA binding domain, termed a 'basic helix-span-helix' motif. The AP-2 genes regulate important aspects of vertebrate embryogenesis and have also been linked to the control of
B Lüscher et al.
Genes & development, 3(10), 1507-1517 (1989-10-01)
The expression of the transcription factor AP-2 recently has been shown to be enhanced during retinoic acid (RA)-induced differentiation of NT2 cells, a human teratocarcinoma cell line. Here we show that this induction of AP-2 mRNA is at the level
Marie Ennen et al.
Free radical biology & medicine, 50(12), 1771-1779 (2011-03-23)
A high basal expression of manganese superoxide dismutase (MnSOD) has been reported in aggressive breast cancer cells, according to an unknown mechanism, and contributes to their invasive abilities. Here, we report the involvement of Sp1 and nuclear factor-κB (NF-κB) transcription
Vanessa Minig et al.
The Journal of biological chemistry, 284(21), 14165-14176 (2009-04-03)
Manganese superoxide dismutase plays a role in breast tumor cell growth, which depends on its constitutive expression. However, the mechanisms responsible for the regulation of constitutive SOD2 gene expression at different malignant phenotype in breast cancers remain to be determined.
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