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Merck
CN

A0928

Aristeromycin

~95%

Synonym(s):

9-(2,3-Dihydroxy-4-[hydroxymethyl]cyclopentyl)adenine

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About This Item

Empirical Formula (Hill Notation):
C11H15N5O3
CAS Number:
19186-33-5
Molecular Weight:
265.27
UNSPSC Code:
51101500
PubChem Substance ID:
24890470
MDL number:
MFCD00078836

Key Documents

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InChI

1S/C11H15N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h3-6,8-9,17-19H,1-2H2,(H2,12,13,14)/t5-,6-,8-,9+/m1/s1

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O

InChI key

UGRNVLGKAGREKS-GCXDCGAKSA-N

assay

~95%

antibiotic activity spectrum

viruses

storage temp.

2-8°C

Gene Information

human ... ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
087K1358
037K1243
017K1544
017K1545
126K1410

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Marloes P Schaddelee et al.
European journal of pharmacology, 504(1-2), 7-15 (2004-10-28)
The objective of this investigation was to characterise the pharmacokinetic-pharmacodynamic correlation of 5'-deoxy-N6-cyclopentyl-adenosine (5'dCPA) in the chronic constriction injury model of neuropathic pain. Following intravenous administration of 5'dCPA (0.30 or 0.75 mg kg(-1)), the time course of the drug concentration
Brian B Gowen et al.
PloS one, 5(9), doi:10-doi:10 (2010-09-24)
A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses
Wei Ye et al.
The Journal of organic chemistry, 71(22), 8641-8643 (2006-10-27)
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes
Fazila Zulfiqar et al.
Nucleosides, nucleotides & nucleic acids, 27(10), 1153-1157 (2008-09-13)
2-Iodonoraristeromycin, 2-iodoaristeromycin and related analogs were synthesized to investigate their inhibitory activities against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolases.
Takauki Ainai et al.
The Journal of organic chemistry, 69(3), 655-659 (2004-01-31)
Dihydroxylation of 4-aryl-1-azido-2-cyclopentenes 6, in which an aryl group is used as a synthetic equivalent of CH(2)OH, was studied to improve the low to moderate stereoselectivity previously reported for cyclopentenes 3 possessing CH(2)X and nitrogen atom-containing groups. 2-Furyl, Ph, and
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