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Merck
CN

A1030

Adenosine Deaminase from calf intestinal mucosa

Type VIII, ammonium sulfate suspension, ~200 units/mg protein

Synonym(s):

Adenosine aminohydrolase

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About This Item

CAS Number:
UNSPSC Code:
12352204
EC Number:
232-817-5
MDL number:
EC Number:
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type

Type VIII

form

ammonium sulfate suspension

specific activity

~200 units/mg protein

storage temp.

2-8°C

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Physical form

Suspension in 3.2 M (NH4)2SO4, pH approx. 6

Analysis Note

Protein determined by biuret.

Other Notes

One unit will deaminate 1.0 μmole of adenosine to inosine per min at pH 7.5 at 25 °C.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Neutropenia and myeloid dysplasia in a patient with delayed-onset adenosine deaminase deficiency.
Keiko Nomura et al.
Pediatric blood & cancer, 60(5), 885-886 (2013-01-22)
Unveiling the binding mode of adenosine deaminase inhibitors to the active site of the enzyme: implication for rational drug design : presented by Maria P. Abbracchio.
Maria Letizia Trincavelli
Purinergic signalling, 9(1), 1-3 (2013-01-29)
Aamira Tariq et al.
Nucleic acids research, 41(4), 2581-2593 (2013-01-01)
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. In mammals, editing levels vary in different tissues, during development, and also in pathogenic conditions. From a screen for repressors of editing
Mary Carmen Pérez-Aguilar et al.
Investigacion clinica, 53(3), 315-324 (2012-12-20)
Adenosine deaminase is an enzyme of the purine metabolism whose function is to convert adenosine to inosine and deoxyadenosine to deoxyinosine. The ecto-ADA1 binding to the cell surface through CD26 contributes to the regulation of cytokines and stimulates the proliferation
John H Fargo et al.
British journal of haematology, 160(4), 547-554 (2012-12-21)
Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983.

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