A1394
4-Aminophenyl α-D-mannopyranoside
≥98% (TLC)
Synonym(s):
p-aminophenyl alpha-D-mannoside
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About This Item
Empirical Formula (Hill Notation):
C12H17NO6
CAS Number:
Molecular Weight:
271.27
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
InChI
1S/C12H17NO6/c13-6-1-3-7(4-2-6)18-12-11(17)10(16)9(15)8(5-14)19-12/h1-4,8-12,14-17H,5,13H2
SMILES string
Nc1ccc(OC2OC(CO)C(O)C(O)C2O)cc1
InChI key
MIAKOEWBCMPCQR-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
optical activity
[α]/D 123.00 to 135.00°, c = 9.00-11.00 mg/mL in methanol
technique(s)
thin layer chromatography (TLC): suitable
color
white to yellow cast
solubility
H2O: soluble
storage temp.
2-8°C
Quality Level
Application
4-Aminophenyl α-D-mannopyranoside is used to modify the surface of liposomes to increase uptake kinetics.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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K Shimura et al.
Journal of biochemistry, 120(6), 1146-1152 (1996-12-01)
Affinophoresis is a type of affinity electrophoresis in which an affinophore, a conjugate of an affinity ligand and a multiply charged soluble matrix, causes a change in migration velocity of proteins which have a specific affinity for the ligand. A
Sumio Chono et al.
The Journal of pharmacy and pharmacology, 59(1), 75-80 (2007-01-18)
The influence of particle size and surface mannose modification on the uptake of liposomes by alveolar macrophages (AMs) was investigated in-vitro and in-vivo. Non-modified liposomes of five different particle sizes (100, 200, 400, 1000 and 2000 nm) and mannosylated liposomes
K Shimura et al.
Journal of chromatography, 400, 353-359 (1987-07-29)
Affinophoresis is an electrophoretic separation technique for biological polymers with the aid of an affinophore, which is a macromolecular polyelectrolyte bearing affinity ligands. The affinophore migrates rapidly in an electric field, and consequently the electrophoretic mobility of molecules having an
Sumio Chono et al.
Drug development and industrial pharmacy, 36(1), 102-107 (2009-08-07)
The effect of surface-mannose modification on aerosolized liposomal delivery to alveolar macrophages (AMs) was evaluated in vitro and in vivo. 4-Aminophenyl-α-D-mannopyranoside (Man) was used for surface-mannose modification, and mannosylated liposomes with various mannosylation rates (particle size: 1000 nm) were prepared.
Xue Ying et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 183-192 (2009-10-06)
Chemotherapy for brain glioma has been of limited value due to the inability of transport of drug across the blood-brain barrier (BBB) and poor penetration of drug into the tumor. For overcoming these hurdles, the dual-targeting daunorubicin liposomes were developed
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