A1520
α-Amylase Inhibitor
≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase), ≥1000 inhibitor U/mg protein (using human salivary α-amylase), lyophilized powder
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About This Item
Product Name
α-Amylase Inhibitor from Triticum aestivum (wheat seed), Type I, lyophilized powder
biological source
Triticum estivum
Quality Segment
type
Type I
form
lyophilized powder
specific activity
≥1000 inhibitor U/mg protein (using human salivary α-amylase), ≥200 inhibitor U/mg protein (using porcine pancreatic α-amylase)
composition
Protein, 35-65% biuret
storage temp.
−20°C
General description
α-Amylases are endoglycosidases, that are classified into glycosyl hydrolase family 13 (1-3).
Application
α-Amylase Inhibitor from Triticum aestivum (wheat seed) has been used to determine its effects on salivary gland (SG) amylase activity. It has also been used to inhibit the activity from the extract from Bemisia tabaci.
Biochem/physiol Actions
α-Amylases can hydrolyze α-(1,4)-D-glycosidic linkages. It participates in the breakdown of starch and glycogen. Inhibiting this enzyme can be used as a strategy to treat dental caries, diabetes, obesity and periodontal diseases.
Competitive inhibitor of human salivary α-amylase. KI = 2.9 nM, compared to a KM of 5.9 mM (calculated per mole of α-1,4-linked maltose residues).
Physical form
Lyophilized powder containing buffer salts as sodium phosphate.
Other Notes
One unit will reduce the activity of two units of α-amylase (A0521) by 50% after pre-incubation at 25 °C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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