A1612
AF-353 hydrochloride
≥98% (HPLC), powder
Synonym(s):
5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride, Ro 4 hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H17IN4O2 · HCl
CAS Number:
Molecular Weight:
436.68
UNSPSC Code:
12352203
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: >10 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
Cl.COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1I
Biochem/physiol Actions
AF-353 is a P2X3, P2X2/3 antagonist.
AF-353 is a potent antagonist of P2X3 homotrimers and P2X2/3 heterotrimers with a pIC50 range of 7.3 - 8.5. The compound does not affect other P2X family members at 300-fold excess concentrations. AF-353 significantly reversed pain behavior in a rat model of bone cancer pain.
Features and Benefits
This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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