A1973
Axl/Fc Chimera human
≥90% (SDS-PAGE), recombinant, expressed in NSO cells
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About This Item
UNSPSC Code:
12352200
MDL number:
General description
Extracellular domain of human Axl (residues 1-442) fused to C-terminal histidine-tagged Fc region of human IgG1.
Biochem/physiol Actions
Member of a tyrosine kinase receptor subfamily shown to be involved in hematopoiesis, embryonic development, tumorigenesis, and testicular function regulation.
Physical form
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline.
Analysis Note
Measured by its ability to bind recombinant human Gas6.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M Faust et al.
Oncogene, 7(7), 1287-1293 (1992-07-01)
We have cloned the mouse homologue of the ufo oncogene. It encodes a novel tyrosine kinase receptor characterized by a unique extracellular domain containing two immunoglobulin-like and two fibronectin type III repeats. Comparison of the predicted ufo amino acid sequences
Safiye E Sarper et al.
Disease models & mechanisms, 12(6) (2019-06-07)
Core binding factor β (Cbfb) is a cofactor of the Runx family of transcription factors. Among these transcription factors, Runx1 is a prerequisite for anterior-specific palatal fusion. It was previously unclear, however, whether Cbfb served as a modulator or as
Nagata, K., et al.
The Journal of Biological Chemistry, 22, 30022-30022 (1996)
K E Crosier et al.
Pathology, 29(2), 131-135 (1997-05-01)
AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role
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