Anti-Epidermal Growth Factor Receptor antibody produced in sheep

EGFR is a glycoprotein receptor that consists of 3 domains: an extracellular domain which modulates ligand binding and receptor dimerization, a single transmembrane domain, and a cytoplasmic domain. EGFR/ErbB1 binds to EGF ligands and is known to form homodimers or heterodimers. Furthermore, EGFR regulates differentiation, growth, movement and apoptosis in a wide range of cells.
Sheep anti-EGFR recognizes rat, mouse, dog, chicken and human EGF receptors. Furthermore, the antibody recognizes the internal domain of the receptor molecule and will block the phosphorylation but will not block EGF binding. The antibody can be used with formalin-fixed, paraffin-embedded tissue sections.

fusion protein (20 amino acid residues) of the human EGF receptor. The sequence is proximal to the phosphorylation region (near the N-terminal sequence).

Sheep anti-EGFR antibody was used to detect EGFR by immunofluorescence in mouse oocyte cumulus cells that were previously fixed in 4% paraformaldehyde

Sheep anti-epidermal growth factor receptor (EGFR) can be used for immunohistochemistry, immunoprecipitation, western blot and immunocytochemistry applications.

0.2 μm filtered solution in 0.15 M phosphate buffered saline, pH 7.5.

Purified by protein G affinity chromatography.

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