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Merck
CN

A2112

Ac-PGP trifluoroacetate salt hydrate

≥98% (HPLC)

Synonym(s):

1-Acetyl-L-prolylglycyl-L-proline, Acetyl Pro-Gly-Pro, Acetyl-proline-glycine-proline, N-α-PGP, acPGP

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About This Item

Empirical Formula (Hill Notation):
C14H21N3O5 · xC2HF3O2 · yH2O
CAS Number:
292171-04-1
Molecular Weight:
311.33 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329770748
MDL number:
MFCD20134196

Key Documents

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shipped in

wet ice

InChI

1S/C14H21N3O5.C2HF3O2.H2O/c1-9(18)16-6-2-4-10(16)13(20)15-8-12(19)17-7-3-5-11(17)14(21)22;3-2(4,5)1(6)7;/h10-11H,2-8H2,1H3,(H,15,20)(H,21,22);(H,6,7);1H2/t10-,11-;;/m0../s1

SMILES string

O.OC(=O)C(F)(F)F.CC(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(O)=O

InChI key

UCOFOXNKITYGTK-ULEGLUPFSA-N

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

deionized water: ≥2 mg/mL

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Ac-PGP is a neutrophil chemoattractant.
N-acetyl Proline-Glycine-Proline (ac-PGP) is a potent and selective neutrophil chemoattractant. It is generated enzymatically from extracellular matrix proteins such as collagen. PGP is generated from native collagen by the action of matrix metalloproteinase–8 (MMP-8) and/or MMP-9, followed by a secondary cleavage by prolyl endopeptidase (PE). N-terminal acetylation of PGP (Ac-PGP) occurs through an unknown mechanism. Both PGP and AcPGP are considered biomarkers and possible therapeutic targets for chronic obstructive pulmonary disease (COPD) and may also be markers for acute pulmonary exacerbation in Cystic Fibrosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4718V

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