A212
L-(+)-2-Amino-4-phosphonobutyric acid
Synonym(s):
L-AP-4, L-AP4
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About This Item
Empirical Formula (Hill Notation):
C4H10NO5P
CAS Number:
Molecular Weight:
183.10
UNSPSC Code:
12352200
MDL number:
SMILES string
N[C@@H](CCP(O)(O)=O)C(O)=O
InChI
1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
InChI key
DDOQBQRIEWHWBT-VKHMYHEASA-N
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Biochem/physiol Actions
mGluR4 and mGluR6 metabotropic glutamate receptor agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Xavier Rovira et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 116-130 (2014-10-25)
Type 4 metabotropic glutamate (mGlu4) receptors are emerging targets for the treatment of various disorders. Accordingly, numerous mGlu4-positive allosteric modulators (PAMs) have been identified, some of which also display agonist activity. To identify the structural bases for their allosteric action
Koji M Nishiguchi et al.
Nature communications, 6, 6006-6006 (2015-01-24)
The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the photoreceptor-mediated
Lea D Bennett et al.
Investigative ophthalmology & visual science, 55(7), 4063-4072 (2014-04-26)
Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very long chain fatty acids (VLC-FAs ≥ C26). Photoreceptors are enriched with VLC polyunsaturated
Benjamin L Murphy-Baum et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(39), 13336-13350 (2015-10-02)
Much of the computational power of the retina derives from the activity of amacrine cells, a large and diverse group of GABAergic and glycinergic inhibitory interneurons. Here, we identify an ON-type orientation-selective, wide-field, polyaxonal amacrine cell (PAC) in the rabbit
Benjamin K Stafford et al.
The Journal of physiology, 592(22), 4877-4889 (2014-09-14)
Postsynaptic AMPA- and NMDA-type glutamate receptors (AMPARs, NMDARs) are commonly expressed at the same synapses. AMPARs are thought to mediate the majority of fast excitatory neurotransmission whereas NMDARs, with their relatively slower kinetics and higher Ca(2+) permeability, are thought to
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