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Merck
CN

A2407

Adrenocorticotropic Hormone Fragment 1-17 human, rat

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C95H145N29O23S
CAS Number:
7266-47-9
Molecular Weight:
2093.41
NACRES:
NA.32
PubChem Substance ID:
329770781
UNSPSC Code:
51111800
MDL number:
MFCD00133033
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)

Key Documents

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InChI

1S/C95H145N29O23S/c1-53(2)78(91(144)109-49-75(128)111-62(22-9-12-35-96)81(134)113-63(23-10-13-36-97)82(135)117-68(93(146)147)26-16-39-106-95(102)103)123-90(143)74-27-17-40-124(74)92(145)67(24-11-14-37-98)112-76(129)48-108-80(133)71(44-56-46-107-61-21-8-7-20-59(56)61)120-83(136)64(25-15-38-105-94(100)101)114-86(139)70(42-54-18-5-4-6-19-54)119-88(141)72(45-57-47-104-52-110-57)121-84(137)65(32-33-77(130)131)115-85(138)66(34-41-148-3)116-89(142)73(51-126)122-87(140)69(118-79(132)60(99)50-125)43-55-28-30-58(127)31-29-55/h4-8,18-21,28-31,46-47,52-53,60,62-74,78,107,125-127H,9-17,22-27,32-45,48-51,96-99H2,1-3H3,(H,104,110)(H,108,133)(H,109,144)(H,111,128)(H,112,129)(H,113,134)(H,114,139)(H,115,138)(H,116,142)(H,117,135)(H,118,132)(H,119,141)(H,120,136)(H,121,137)(H,122,140)(H,123,143)(H,130,131)(H,146,147)(H4,100,101,105)(H4,102,103,106)/t60-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,78-/m0/s1

SMILES string

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

MXNMAFWEFLFAJN-QBQLSIIBSA-N

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01189

storage temp.

−20°C

Quality Level

200

Gene Information

human ... POMC(5443)

Related Categories

Biochem/physiol Actions

ACTH fragment with moderate adrenocorticotropic and melanocyte-stimulating activities.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000490810
0000490810
0000454429
0000454429
0000429321

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P Paccotti et al.
Chronobiologia, 15(4), 279-287 (1988-10-01)
We evaluated the effect of an acute oral administration of 2 dosages (100 and 1 mg) of melatonin (MT) vs placebo (PL) on pituitary release of LH, FSH, TSH and PRL after GnRH + TRH and on the adrenocortical release
M Terzolo et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 5(2), 83-94 (1991-06-01)
The aim of the present study was to analyze the effects of exogenous melatonin (MT) upon pituitary and adrenal responsiveness to releasing hormones in different phases of the menstrual cycle. We evaluated the response of FSH and LH to 100
Skin POMC peptides. Their binding affinities and activation of the human MC1 receptor.
M Tsatmalia et al.
Annals of the New York Academy of Sciences, 885, 466-469 (2000-05-19)
Y Touitou et al.
European journal of clinical pharmacology, 38(2), 149-152 (1990-01-01)
The effect of injection of ACTH 1-17 on the secretion of GH has been examined at three different circadian stages (07, 14 and 21 h) in the winter. Each week for six consecutive weeks the subjects were investigated before and
[Use of synthetic ACTH in combination with low-dose tricyclic antidepressants in chronic deafferentation pain].
E Salvi et al.
Minerva anestesiologica, 54(6), 275-278 (1988-06-01)
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