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A2504

6-Aminocaproic acid

Name: 6-Aminocaproic acid
Brand: SIGMA

≥99% (titration), powder

Synonym(s):

ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

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About This Item

Linear Formula:

H₂N(CH₂)₅CO₂H

CAS Number:

60-32-2

Molecular Weight:

131.17

UNSPSC Code:

12352202

NACRES:

NA.77

PubChem Substance ID:

24890662

EC Number:

200-469-3

Beilstein/REAXYS Number:

906872

MDL number:

MFCD00008238

Assay:

≥99% (titration)

Form:

powder

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biological source

synthetic

Quality Level

300

assay

≥99% (titration)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

mp

207-209 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL

SMILES string

NCCCCCC(O)=O

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

InChI key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

Gene Information

human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)

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Acids for Laboratory, Analysis, and Regulated Applications

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Storage Class

11 - Combustible Solids

flash_point_f

404.6 - 408.2 °F

flash_point_c

207 - 209 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device.

Kazuki Yamamoto et al.

Lab on a chip, 21(10), 1897-1907 (2021-05-20)

Engineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the physically separated structures of motor neurons (MNs) and skeletal muscle

Stabilizing effect of epsilon-aminocaproic acid on allergenic extracts.

E M Van Hoeyveld et al.

The Journal of allergy and clinical immunology, 76(4), 543-550 (1985-10-01)

The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4 degrees C for 12 months and at 37 degrees

S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.

Moamen Bydoun et al.

Molecular oncology, 12(11), 1895-1916 (2018-07-17)

Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome

Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies.

Brian Hutton et al.

BMJ (Clinical research ed.), 345, e5798-e5798 (2012-09-13)

To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and

Conserved anti-inflammatory effects and sensing of butyrate in zebrafish.

Pradeep Manuneedhi Cholan et al.

Gut microbes, 12(1), 1-11 (2020-10-17)

Short-chain fatty acids (SCFAs) are produced by microbial fermentation of dietary fiber in the gut. Butyrate is a particularly important SCFA with anti-inflammatory properties and is generally present at lower levels in inflammatory diseases associated with gut microbiota dysbiosis in

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Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

Global Trade Item Number

SKU	GTIN
A2504-500G	04061833350355
A2504-25G	04061833350348
A2504-100G	04061833350331
A2504-5KG	04061832938813
A2504-1KG	04061826740866

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