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Merck
CN

A2734

α5IA

≥98% (HPLC)

Synonym(s):

1,2,4-Triazolo[3,4-a]phthalazine, 3-(5-methyl-3-isoxazolyl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy]-, 3-(5-Methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4-yl)methoxy-1,2,4-triazolo[3,4-a]phthalazine

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About This Item

Empirical Formula (Hill Notation):
C17H14N8O2
CAS Number:
215874-86-5
Molecular Weight:
362.35
NACRES:
NA.77
PubChem Substance ID:
329770794
UNSPSC Code:
12352200
MDL number:
MFCD09832717

Key Documents

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InChI key

NZMJFRXKGUCYNP-UHFFFAOYSA-N

SMILES string

Cc1cc(no1)-c2nnc3c4ccccc4c(OCc5cn(C)nn5)nn23

InChI

1S/C17H14N8O2/c1-10-7-14(22-27-10)16-20-19-15-12-5-3-4-6-13(12)17(21-25(15)16)26-9-11-8-24(2)23-18-11/h3-8H,9H2,1-2H3

assay

≥98% (HPLC)

form

powder

color

off-white to light yellow

solubility

DMSO: >2 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

Biochem/physiol Actions

α5IA is a selective inverse agonist for Α5 subtype of GABAA receptor with a higher intrinsic activity at the A5 subtype than other drugs. α5IA enhances cognition in laboratory animals without being proconvulsant or anxiogenic. α5IA acts as an "alcohol antagonist," markedly reducing the amnesic effect of alcohol and partially attenuating sedation, similar to Ro15-4513, but without the anxiogenic effect. α5IA offers promise as a tool to study cognitive disorders, memory function, and treatment of alcohol-related disorders.
α5IA is a selective inverse agonist for a5 subtype of GABAA receptor.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
050M4628
039K46091
039K4609

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