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Merck
CN

A2804

Ampicillin sodium salt

powder

Synonym(s):

D-(−)-α-Aminobenzylpenicillin sodium salt

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About This Item

Empirical Formula (Hill Notation):
C16H18N3NaO4S
CAS Number:
69-52-3
Molecular Weight:
371.39
EC Number:
200-708-1
UNSPSC Code:
12352200
PubChem Substance ID:
24890695
Beilstein/REAXYS Number:
4119211
MDL number:
MFCD00064313

Key Documents

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InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

sterility

γ-irradiated

form

powder

color

white to slight yellow

mp

215 °C (dec.) (lit.)

solubility

sterile water: 5-20 mg/mL (as a stock solution)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

storage temp.

2-8°C

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General description

Chemical structure: β-lactam

Application

Recommended for use in molecular biology applications at 20-50 μg/ml.

Biochem/physiol Actions

Mode of Action: This is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with β-lactamase cleaves the β-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Preparation Note

Prepare stock solutions directly in the vial at any concentration in the recommended range. Stock solutions should be stored at −20 °C. Stable at 37 °C for 3 days.

Analysis Note

USP potency testing is carried out on control vials after γ-irradiation to assure full biological activity (except where noted).

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1A - Skin Sens. 1A

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
109K6073
057K6083
127H028615
101H67881
081H66781

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