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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADAM10(102)
General description
ADAM is a member of the disintegrin and metalloproteinase family of proteins which possess both adhesion and zinc protease functions. ADAM-10 is a sheddase with both a secreted and membrane-bound form. ADAM-10 null mice are embryonically lethal with neural and cardiac defects. Rabbit anti-ADAM-10 antibody can localize human ADAM 10 and does not detect other ADAMs.
Recognizes the furin cleavage site (58-60 kDa) of ADAM-10. Detects the latent form of the enzyme.
Immunogen
synthetic peptide corresponding to the prohormone convertase (PC) cleavage site of human ADAM-10.
Application
Rabbit anti-ADAM-10 antibody has been used for western blot assays.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Regulatory Information
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Hiroshi Tanahashi et al.
Neuroscience letters, 439(3), 293-297 (2008-06-07)
In a previous study, we reported that Alzheimer's disease-associated presenilin-2 interacts with a LIM-domain protein, namely, DRAL/FHL2/SLIM3. In this study, we investigated whether DRAL modifies the metabolism of the amyloid precursor protein (APP). We used small interfering RNA (siRNA) to
Ting Wang et al.
Phytotherapy research : PTR, 33(4), 1074-1083 (2019-02-16)
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The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
Darren F Seals et al.
Genes & development, 17(1), 7-30 (2003-01-07)
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