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Merck
CN

A2851

Sigma-Aldrich

Anti-ADAM-10, Prohormone Convertase Activation Site antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase-10, Anti-Kuzbanian, Anti-MADM

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About This Item

MDL number:
MFCD04040147
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

O14672

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAM10(102)

General description

ADAM is a member of the disintegrin and metalloproteinase family of proteins which possess both adhesion and zinc protease functions. ADAM-10 is a sheddase with both a secreted and membrane-bound form. ADAM-10 null mice are embryonically lethal with neural and cardiac defects. Rabbit anti-ADAM-10 antibody can localize human ADAM 10 and does not detect other ADAMs.
Recognizes the furin cleavage site (58-60 kDa) of ADAM-10. Detects the latent form of the enzyme.

Immunogen

synthetic peptide corresponding to the prohormone convertase (PC) cleavage site of human ADAM-10.

Application

Rabbit anti-ADAM-10 antibody has been used for western blot assays.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
082K1621

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Hiroshi Tanahashi et al.
Neuroscience letters, 439(3), 293-297 (2008-06-07)
In a previous study, we reported that Alzheimer's disease-associated presenilin-2 interacts with a LIM-domain protein, namely, DRAL/FHL2/SLIM3. In this study, we investigated whether DRAL modifies the metabolism of the amyloid precursor protein (APP). We used small interfering RNA (siRNA) to
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Osteoporosis is characterized by low bone mineral density and microarchitectural deterioration of bone tissue. N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (MBOC) is one of the macamides isolated from Maca (Lepidium meyenii Walp.), a cruciferous plant from the Andes of Peru. In this study, C3H/10T1/2 mesenchymal
The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
Darren F Seals et al.
Genes & development, 17(1), 7-30 (2003-01-07)

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