A3180
Amyloid β-Protein Fragment 12-28
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C89H135N25O25
CAS Number:
Molecular Weight:
1955.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc2cnc[nH]2)NC(=O)C(N)C(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc3ccccc3)C(=O)NC(Cc4ccccc4)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(O)=O
Gene Information
human ... APP(351)
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Amino Acid Sequence
Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
Biochem/physiol Actions
Impairs post-training memory in mice upon injection into limbic system structures.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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E M Castaño et al.
Biochemical and biophysical research communications, 141(2), 782-789 (1986-12-15)
Two synthetic peptides corresponding to the reported 28-residue sequence of Alzheimer's Disease beta-protein (SP28) and to residues 12-28 (SP17) were used to form fibrils in vitro. Synthetic fibrils bound Congo Red and closely resembled amyloid fibrils isolated from leptomeninges and
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