A3359
Anti-Annexin I antibody,Mouse monoclonal
clone ANEX 5E4/1, purified from hybridoma cell culture
Synonym(s):
Anti-ANX1, Anti-ANXA1, Anti-Annexin A1, Anti-LPC1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352202
Conjugate:
unconjugated
Clone:
ANEX 5E4/1, monoclonal
Application:
ICC, WB
Citations:
8
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
ANEX 5E4/1, monoclonal
form
buffered aqueous solution
mol wt
antigen ~37 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.5 mg/mL
technique(s)
immunocytochemistry: suitable, western blot: 4-8 μg/mL using A431 cells extract
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Annexin I belongs to the annexin superfamily. It is associated with cellular membranes in the presence of Ca2+. The protein has a large conserved core domain (~30kDa) required for calcium and phospholipid association. This gene is widely expressed in tissues.
Immunogen
mixture of native membrane proteins from human bone tissues, which includes whole native annexin proteins.
Application
Monoclonal Anti-Annexin I antibody produced in mouse has been used in western blotting.
Biochem/physiol Actions
Annexin I is an anti-inflammatory factor and plays an important role in neuroprotection. It is associated with the removal of apoptotic cells, protects from ischemia-like injury and prevents hepatic inflammation. Annexin I also protects against the breakdown of blood-brain-barrier in Alzheimer′s disease. It is involved in the homeostasis of innate immune system by mediating immune cells (for instance, neutrophils and macrophages).
Physical form
Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Related Content
A fragmented form of annexin A1 is secreted from C2C12 myotubes by electric pulse-induced contraction.
Goto-Inoue N
Molecular and Cellular Biochemistry, 411, 173-173 (2016)
W F Lo et al.
Journal of immunology (Baltimore, Md. : 1950), 162(9), 5398-5406 (1999-05-05)
Despite being a major group of intracellular pathogens, the role of class I-restricted T cells in the clearance of Gram-negative bacteria is not resolved. Using a murine typhoid model, a role for class I-restricted T cells in the immune response
Downregulation of Annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma.
Huang L
Oncology Letters, 12, 5229-5229 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3359-200UL | 04061838029621 |