A3759
p-Aminohippuric acid sodium salt
Synonym(s):
N-(p-Aminobenzoyl)glycine
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About This Item
Linear Formula:
C9H9N2O3Na
CAS Number:
Molecular Weight:
216.17
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
202-309-8
MDL number:
InChI key
IGACXVXMVJUFOL-UHFFFAOYSA-N
InChI
1S/C9H10N2O3.Na.H/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13;;/h1-4H,5,10H2,(H,11,14)(H,12,13);;
SMILES string
[Na].Nc1ccc(cc1)C(=O)NCC(O)=O
assay
≥98% (TLC)
form
powder
color
white to off-white
application(s)
cell analysis
Biochem/physiol Actions
Para-Aminohippuric acid (PAH), OAT-1 specific, is used to help differentiate and characterized organic anion transporter (OAT) isoforms.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chiao-Shih Tseng et al.
Advances in pharmacological sciences, 2011, 204501-204501 (2011-07-09)
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and
Chi Chun Wong et al.
Biochemical pharmacology, 81(7), 942-949 (2011-01-20)
Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with
Nadiya Bakhiya et al.
Toxicology, 264(1-2), 74-79 (2009-08-01)
Aristolochic acid (AA), present in Aristolochia species, is the major causative agent in the development of severe renal failure and urothelial cancers in patients with AA nephropathy. It may also be a cause of Balkan endemic nephropathy. Epithelial cells of
M M Al-Bataineh et al.
Journal of veterinary pharmacology and therapeutics, 35(3), 209-215 (2011-06-01)
Mammary epithelial cells express a diversity of membrane transporters including members of organic cation and organic anion (OAT) transporter subfamilies. Four mammal OAT isoforms have been identified: OAT-1, OAT-2, OAT-3, and OAT-4. The pharmacological significance of OAT isoforms has been
Andrew A Udy et al.
Critical care (London, England), 18(6), 657-657 (2014-11-30)
The aim of this study was to explore changes in glomerular filtration (GFR) and renal tubular function in critically ill patients at risk of augmented renal clearance (ARC), using exogenous marker compounds. This prospective, observational pharmacokinetic (PK) study was performed
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