A3851
Anti-ADAM-15, Cytoplasmic Domain antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-A Disintegrin And Metalloproteinase-15, Anti-MDC15, Anti-Metargidin
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About This Item
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADAM15(8751)
General description
ADAM-15 (MDC-15, metargidin) is a membrane-anchored disintegrin and metalloprotease that is present on the cell surface. ADAM-15 may play a role in cell-cell interactions through its association with integrins. Studies have reported that ADAM15 is involved in the migration of mesangial cells.
Rabbit anti-ADAM-15, cytoplasmic domain antibody localizes human ADAM15. By immunoblotting against the reduced protein, the antibody recognizes bands of 110kDa (zymogen) and 90kDa (furin-processed form) of ADAM15. A series of cleaved products at 55kDa and 40kDa can also be seen in reduced immunoblots of cell lysates.
Rabbit anti-ADAM-15, cytoplasmic domain antibody localizes human ADAM15. By immunoblotting against the reduced protein, the antibody recognizes bands of 110kDa (zymogen) and 90kDa (furin-processed form) of ADAM15. A series of cleaved products at 55kDa and 40kDa can also be seen in reduced immunoblots of cell lysates.
Immunogen
synthetic peptide corresponding to the cytoplasmic domain of human ADAM-15.
Application
Rabbit anti-ADAM-15, cytoplasmic domain antibody can be used for western blot applications at 1:1,000.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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John Martin et al.
The Journal of biological chemistry, 277(37), 33683-33689 (2002-07-02)
Mesangial cells (MC) occupy the core of the renal glomerulus and are surrounded by a mesangial matrix. In certain diseases, MC migrate through this matrix into the pericapillary space. The mechanisms involved, however, are poorly understood. Members of the ADAM
X P Zhang et al.
The Journal of biological chemistry, 273(13), 7345-7350 (1998-04-29)
MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD tripeptide in its disintegrin-like domain. MDC-15 is potentially involved in cell-cell interactions through its interaction with integrins. We
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