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Merck
CN

A3851

Sigma-Aldrich

Anti-ADAM-15, Cytoplasmic Domain antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase-15, Anti-MDC15, Anti-Metargidin

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About This Item

MDL number:
MFCD03702124
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

Q13444

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAM15(8751)

General description

ADAM-15 (MDC-15, metargidin) is a membrane-anchored disintegrin and metalloprotease that is present on the cell surface. ADAM-15 may play a role in cell-cell interactions through its association with integrins. Studies have reported that ADAM15 is involved in the migration of mesangial cells.
Rabbit anti-ADAM-15, cytoplasmic domain antibody localizes human ADAM15. By immunoblotting against the reduced protein, the antibody recognizes bands of 110kDa (zymogen) and 90kDa (furin-processed form) of ADAM15. A series of cleaved products at 55kDa and 40kDa can also be seen in reduced immunoblots of cell lysates.

Immunogen

synthetic peptide corresponding to the cytoplasmic domain of human ADAM-15.

Application

Rabbit anti-ADAM-15, cytoplasmic domain antibody can be used for western blot applications at 1:1,000.

Physical form

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Lot/Batch Number
082K1662

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John Martin et al.
The Journal of biological chemistry, 277(37), 33683-33689 (2002-07-02)
Mesangial cells (MC) occupy the core of the renal glomerulus and are surrounded by a mesangial matrix. In certain diseases, MC migrate through this matrix into the pericapillary space. The mechanisms involved, however, are poorly understood. Members of the ADAM
X P Zhang et al.
The Journal of biological chemistry, 273(13), 7345-7350 (1998-04-29)
MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD tripeptide in its disintegrin-like domain. MDC-15 is potentially involved in cell-cell interactions through its interaction with integrins. We

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