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A3913

L-Argininamide dihydrochloride

Name: <SC>L</SC>-Argininamide dihydrochloride
Brand: SIGMA

≥98%, suitable for ligand binding assays

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₅N₅O · 2HCl

CAS Number:

14975-30-5

Molecular Weight:

246.14

UNSPSC Code:

12352209

PubChem Substance ID:

24890827

NACRES:

NA.26

MDL number:

MFCD00058286

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Product Name

L-Argininamide dihydrochloride,

assay

≥98%

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C6H15N5O.ClH/c7-4(5(8)12)2-1-3-11-6(9)10;/h4H,1-3,7H2,(H2,8,12)(H4,9,10,11);1H/t4-;/m0./s1

InChI key

BPQLYFCEVVKLLX-WCCKRBBISA-N

Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Amino Acids – Building Blocks of Life Science

Application

L-Argininamide dihydrochloride has been used as an additive to compare its effect over L-arg in egg lysozyme refolding studies. It has also been used as a component of substrate stock solution for enzymatic kyotorphin synthesis.

Biochem/physiol Actions

L-Argininamide (L-Arm) is a hydrophilic amino acid derivative that is used as a model compound in physicochemical characteristic studies of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H370

pcodes

P260 - P264 - P270 - P301 + P312 - P308 + P311 - P405

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 1

target_organs

Eyes

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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N(G)-Acyl-argininamides as NPY Y(1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity.

Stefan Weiss et al.

Bioorganic & medicinal chemistry, 18(17), 6292-6304 (2010-08-07)

N(G)-Acylated argininamides, covering a broad range of lipophilicity (calculated logD values: -1.8-12.5), were synthesized and investigated for NPY Y(1) receptor (Y(1)R) antagonism, Y(1)R affinity and stability in buffer (N(G)-deacylation, yielding BIBP 3226). Broad structural variation of substituents was tolerated. The

Aptamers with fluorescence-signaling properties.

Razvan Nutiu et al.

Methods (San Diego, Calif.), 37(1), 16-25 (2005-10-04)

Aptamers are single-stranded DNA or RNA molecules with ligand-binding capabilities. Signaling aptamers refer to aptamers or modified aptamers with recordable signal generation ability. Fluorescence-signaling aptamers, in particular, are valuable molecular tools that can be used to establish important techniques or

Biomolecular sensor based on fluorescence-labeled aptamer.

Hiroaki Ozaki et al.

Bioorganic & medicinal chemistry letters, 16(16), 4381-4384 (2006-06-08)

Fluorescent DNA probes for L-argininamide were developed by a combination of DNA aptamers and fluorophore-quencher pairs. These molecules were synthesized by a combination of pre- and post-synthetic modification methods. The fluorescence-labeled aptamer could detect L-argininamide specifically. The binding affinities were

L-argininamide improves the refolding more effectively than L-arginine.

Hiroyuki Hamada et al.

Journal of biotechnology, 130(2), 153-160 (2007-04-17)

L-arginine (Arg) is a widely used additive for suppressing protein aggregation during refolding. Systematic screening of Arg analogs provides superior additives that enhance the refolding yield more effectively than Arg. The refolding yield of hen egg lysozyme in the presence

Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist.

Max Keller et al.

Journal of medicinal chemistry, 51(24), 8168-8172 (2008-12-05)

Synthesis and characterization of (R)-N(alpha)-(2,2-diphenylacetyl)-N-(4-hydroxybenzyl)-N(omega)-([2,3-(3)H]-propanoyl)argininamide ([(3)H]-UR-MK114), an easily accessible tritium-labeled NPY Y(1) receptor (Y(1)R) antagonist (K(B): 0.8 nM, calcium assay, HEL cells) derived from the (R)-argininamide BIBP 3226, is reported. The radioligand binds with high affinity (K(D), saturation: 1.2 nM

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Global Trade Item Number

SKU	GTIN
A3913-5G	04061832421087
A3913-1G	04061826055403

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