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A4021

Sigma-Aldrich

Nε-Acetyl-L-lysine

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Synonym(s):
N6-acetyl-L-lysine
Linear Formula:
CH3CONH(CH2)4CH(NH2)CO2H
CAS Number:
Molecular Weight:
188.22
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Assay

≥98% (TLC)

Quality Level

form

powder

concentration

50 mg/mL in 80% acetic acid

color

colorless to white

mp

250 °C (dec.) (lit.)

storage temp.

−20°C

SMILES string

CC(=O)NCCCC[C@H](N)C(O)=O

InChI

1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1

InChI key

DTERQYGMUDWYAZ-ZETCQYMHSA-N

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1 of 4

This Item
A2010P4510A3626
Nε-Acetyl-L-lysine

Sigma-Aldrich

A4021

Nε-Acetyl-L-lysine

Nα-Acetyl-L-lysine

Sigma-Aldrich

A2010

Nα-Acetyl-L-lysine

Poly-ε-Cbz-L-lysine mol wt 500-4,000

Sigma-Aldrich

P4510

Poly-ε-Cbz-L-lysine

Nα-Acetyl-L-ornithine

Sigma-Aldrich

A3626

Nα-Acetyl-L-ornithine

form

powder

form

powder

form

powder

form

powder

color

colorless to white

color

colorless to white

color

white

color

colorless to white

mp

250 °C (dec.) (lit.)

mp

256-258 °C (dec.) (lit.)

mp

-

mp

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

concentration

50 mg/mL in 80% acetic acid

concentration

-

concentration

-

concentration

-

Biochem/physiol Actions

Nε-Acetyl-L-lysine (L-AcK) is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Customers Also Viewed

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Ying Huang et al.
Molecular bioSystems, 6(4), 683-686 (2010-03-20)
By overexpressing the C-terminal domain of the ribosomal protein L11 to decrease release factor 1-mediated termination of protein translation, enhanced amber suppression is achieved in E. coli. This enhanced amber suppression efficiency allows the genetic incorporation of three N(epsilon)-acetyl-l-lysines into
Morten B Trelle et al.
Analytical chemistry, 80(9), 3422-3430 (2008-03-15)
Tandem mass spectrometry (MS/MS) is a powerful tool for characterization of post-translationally modified proteins, including epsilon-N-acetyllysine-containing species. Previous reports indicate that epsilon-N-acetyllysine immonium ions are useful marker ions for peptides containing epsilon-N-acetyllysine, but the specificity and sensitivity of these ions
K Hoffmann et al.
Die Pharmazie, 55(8), 601-606 (2000-09-16)
Inhibitors of histone deacetylase (HD) are of great potential as new drugs due to their ability to influence transcriptional regulation and to induce apoptosis or differentiation in cancer cells. So far only radioactive enzyme activity assays or in-vivo assays with
C Crane-Robinson et al.
Methods (San Diego, Calif.), 12(1), 48-56 (1997-05-01)
Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. To determine the spatial and temporal distribution of this reversible posttranslational modification, affinity-purified polyclonal antibodies recognizing the epitope epsilon-acetyllysine have been
S L Hazen et al.
The Journal of biological chemistry, 272(27), 16990-16998 (1997-07-04)
Activated human phagocytes employ the myeloperoxidase-H2O2-Cl- system to convert L-tyrosine to p-hydroxyphenylacetaldehyde (pHA). We have explored the possibility that pHA covalently reacts with proteins to form Schiff base adducts, which may play a role in modifying targets at sites of

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