A4047
N-(5-Aminopentyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
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Empirical Formula (Hill Notation):
C15H19ClN2O2S · HCl
CAS Number:
Molecular Weight:
363.30
UNSPSC Code:
41116107
MDL number:
SMILES string
Cl.NCCCCCNS(=O)(=O)c1ccc2c(Cl)cccc2c1
storage temp.
2-8°C
Biochem/physiol Actions
A calmodulin antagonist.
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H Hidaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(7), 4354-4357 (1981-07-01)
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. Autoradiographic studies using tritiated W-7 showed that this compound penetrates the cell membrane, is distributed mainly in the cytoplasm, and inhibits proliferation
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