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Merck
CN

A4336

Sigma-Aldrich

4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid

≥95% (HPLC)

Synonym(s):

FN-439

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About This Item

Empirical Formula (Hill Notation):
C23H34N6O6
CAS Number:
124168-73-6
Molecular Weight:
490.55
MDL number:
MFCD00237459
UNSPSC Code:
12352200
PubChem Substance ID:
24890847
NACRES:
NA.32

Key Documents

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Assay

≥95% (HPLC)

form

powder

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

CC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c2ccc(N)cc2)C(=O)N[C@H](C)C(=O)NO

InChI

1S/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1

InChI key

WWHUHFFMOPIVKB-OLMNPRSZSA-N

Gene Information

human ... COL1A1(1277), MMP1 (includes EG:4312)
mouse ... COL1A1(12842), MMP1 (includes EG:4312)
rat ... COL1A1(29393), MMP1 (includes EG:4312)

Amino Acid Sequence

Abz-Gly-Pro-Leu-Ala-HA

Biochem/physiol Actions

Collagenase Inhibitor

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT9062
BCBH3406V
BCBB5780V
BCBB5780
1401735

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K Kigasawa et al.
Japanese journal of ophthalmology, 39(1), 35-42 (1995-01-01)
The inhibitory activity of a new peptidyl collagenase inhibitor, FN-439 or tetrapeptidyl hydroxamic acid (H2N-C6H4-CO-Gly-L-Pro-D-Leu-D-Ala-NHOH), was determined against vertebrate collagenases derived from human fibroblast, human polymorphonuclear leukocyte (PMN) and tadpole skin. In addition, the effect of FN-439 in inhibiting corneal
D R Garmer et al.
Proteins, 31(1), 42-60 (1998-04-29)
We investigated the binding properties of the metalloprotease inhibitors hydroxamate, methanethiolate, and methylphosphoramidate to a model coordination site occurring in several Zn2+ metalloproteases, including thermolysin. This was carried out using both the SIBFA (sum of interactions between fragments ab initio-computed)
H Anan et al.
Journal of endodontics, 22(12), 668-673 (1996-12-01)
To investigate the effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) in the root canal treatment of apical periodontitis, we studied the healing process of experimentally induced periapical lesions in rats by using immunohistochemical
Sarah L Tressel et al.
EMBO molecular medicine, 3(7), 370-384 (2011-05-19)
Sepsis is a deadly disease characterized by the inability to regulate the inflammatory-coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorly understood and has hampered the development of effective therapeutics. Matrix metalloproteases
S Odake et al.
Biochemical and biophysical research communications, 199(3), 1442-1446 (1994-03-30)
Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A water soluble inhibitor, p-NH2-Bz-Gly-Pro-D-Leu-D-Ala-NHOH (FN-439) inhibited interstitial and granulocyte collagenases, granulocyte gelatinase and skin fibroblast stromelysin
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