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A4336

4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid

≥95% (HPLC)

Synonym(s):

FN-439

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About This Item

Empirical Formula (Hill Notation):
C23H34N6O6
CAS Number:
124168-73-6
Molecular Weight:
490.55
NACRES:
NA.32
PubChem Substance ID:
24890847
UNSPSC Code:
12352200
MDL number:
MFCD00237459
Assay:
≥95% (HPLC)
Form:
powder
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assay

≥95% (HPLC)

form

powder

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

CC(C)C[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c2ccc(N)cc2)C(=O)N[C@H](C)C(=O)NO

InChI

1S/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1

InChI key

WWHUHFFMOPIVKB-OLMNPRSZSA-N

Gene Information

human ... COL1A1(1277), MMP1 (includes EG:4312)
mouse ... COL1A1(12842), MMP1 (includes EG:4312)
rat ... COL1A1(29393), MMP1 (includes EG:4312)

Biochem/physiol Actions

Collagenase Inhibitor

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT9062
BCBH3406V
BCBB5780V
BCBB5780
1401735

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Lina María Preciado et al.
Toxins, 12(1) (2019-12-22)
Snake bite envenoming is a public health problem that was recently included in the list of neglected tropical diseases of the World Health Organization. In the search of new therapies for the treatment of local tissue damage induced by snake
K Kigasawa et al.
Japanese journal of ophthalmology, 39(1), 35-42 (1995-01-01)
The inhibitory activity of a new peptidyl collagenase inhibitor, FN-439 or tetrapeptidyl hydroxamic acid (H2N-C6H4-CO-Gly-L-Pro-D-Leu-D-Ala-NHOH), was determined against vertebrate collagenases derived from human fibroblast, human polymorphonuclear leukocyte (PMN) and tadpole skin. In addition, the effect of FN-439 in inhibiting corneal
S Odake et al.
Chemical & pharmaceutical bulletin, 39(6), 1489-1494 (1991-06-01)
To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38, 1007-1011, 1990). Among the series of tetrapeptidyl derivatives synthesized, R-Gly-Pro-Leu-Ala-NHOH and R-Gly-Pro-D-Leu-D-Ala-NHOH
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Global Trade Item Number

SKUGTIN
A4336-5MG04061833258156