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Merck
CN

A4469

Monoclonal Anti-ACTR/AIB1 antibody produced in mouse

clone AX 15, ascites fluid

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02095791

Key Documents

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Product Name

Monoclonal Anti-ACTR/AIB1 antibody produced in mouse, clone AX 15, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

AX 15, monoclonal

mol wt

antigen 150 kDa

contains

0.035% sodium azide
30% glycerol

species reactivity

human

technique(s)

immunoprecipitation (IP): 15 μL using 500 μg of a BG-1 ovarian cell RIPA lysate.
western blot (chemiluminescent): 1:500 using RIPA lysates of BG-1 ovarian cancer cells

isotype

IgG

UniProt accession no.

Q9Y6Q9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... NCOA3(8202)

Application

Mouse monoclonal can be used for immunoprecipitation (15μL using 500μg of a BG-1 ovarian cell RIPA lysate) and western blot (1:500, using RIPA lysates of BG-1 ovarian cancer cells) assays.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

ACTR associates with estrogen receptors in breast and ovarian cancers and stimulates transcription. Hence, ACTR has been implicated in the carcinogenesis of breast and ovarian tumors. Mouse monoclonal Anti-ACTR/AIB1 antibody recognizes human ACTR (150kD) and another doublet (110kD) by immunoblotting.
ACTR, a nuclear receptor coactivator, is also referred to as amplified in breast cancer 1 (AIB1), thyroid hormone receptor activator molecule-1 (TRAM-1), receptor-associated coactivator 3 (RAC3 and SRC3).

Immunogen

GST fusion protein containing amino acids 605-1294 of human ACTR.

Physical form

The product is supplied as mouse ascites fluid, containing 30% glycerol and 0.035% sodium azide

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Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
089H0083
070K0254

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S L Anzick et al.
Science (New York, N.Y.), 277(5328), 965-968 (1997-08-15)
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes

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