A4469
Monoclonal Anti-ACTR/AIB1 antibody produced in mouse
clone AX 15, ascites fluid
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About This Item
Conjugate:
unconjugated
Clone:
AX 15, monoclonal
Application:
IP, WB CL
Citations:
1
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
AX 15, monoclonal
mol wt
antigen 150 kDa
contains
0.035% sodium azide, 30% glycerol
species reactivity
human
technique(s)
immunoprecipitation (IP): 15 μL using 500 μg of a BG-1 ovarian cell RIPA lysate., western blot (chemiluminescent): 1:500 using RIPA lysates of BG-1 ovarian cancer cells
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NCOA3(8202)
General description
ACTR associates with estrogen receptors in breast and ovarian cancers and stimulates transcription. Hence, ACTR has been implicated in the carcinogenesis of breast and ovarian tumors. Mouse monoclonal Anti-ACTR/AIB1 antibody recognizes human ACTR (150kD) and another doublet (110kD) by immunoblotting.
ACTR, a nuclear receptor coactivator, is also referred to as amplified in breast cancer 1 (AIB1), thyroid hormone receptor activator molecule-1 (TRAM-1), receptor-associated coactivator 3 (RAC3 and SRC3).
Immunogen
GST fusion protein containing amino acids 605-1294 of human ACTR.
Application
Mouse monoclonal can be used for immunoprecipitation (15μL using 500μg of a BG-1 ovarian cell RIPA lysate) and western blot (1:500, using RIPA lysates of BG-1 ovarian cancer cells) assays.
Physical form
The product is supplied as mouse ascites fluid, containing 30% glycerol and 0.035% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
Regulatory Information
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S L Anzick et al.
Science (New York, N.Y.), 277(5328), 965-968 (1997-08-15)
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes
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