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Merck
CN

A4473

Sigma-Aldrich

Amyloid β-Protein Fragment 1-40 amide trifluoroacetate salt

≥95% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C194H296N54O57S · xC2HF3O2
Molecular Weight:
4328.82 (free base basis)
MDL number:
UNSPSC Code:
12352202
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Assay

≥95% (HPLC)

form

lyophilized powder

mol wt

4331

composition

Protein content, ≥70%

solubility

H2O: soluble

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-NH2

Other Notes

Amide form of Aβ [1-40]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Lilia Y Kucheryavykh et al.
International journal of molecular sciences, 19(6) (2018-06-13)
While it is known that amyloid beta (Aβ) deposits are found in different tissues of both Alzheimer’s disease (AD) patients and healthy individuals, there remain questions about the physiological role of these deposits, the origin of the Aβ peptide, and
L K Simmons et al.
Molecular pharmacology, 45(3), 373-379 (1994-03-01)
Amyloid beta peptide (A beta), the major protein constituent of senile plaques in patients with Alzheimer's disease, is believed to facilitate the progressive neurodegeneration that occurs in the latter stages of this disease. Early attempts to characterize the structure-activity relationship

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