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A4475

Anti-Annexin VII antibody, Mouse monoclonal

Name: Anti-Annexin VII antibody, Mouse monoclonal
Brand: SIGMA

clone 203-217/6, purified from hybridoma cell culture

Synonym(s):

Synexin

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD03792412

Conjugate:

unconjugated

Clone:

203-217/6, monoclonal

Application:

ARR, ICC, IHC (f), WB

Citations:

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

203-217/6, monoclonal

form

buffered aqueous solution

mol wt

antigen 47-51 kDa

species reactivity

mouse, canine, rat, chicken, bovine, human, rabbit

technique(s)

immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde, immunohistochemistry (frozen sections): suitable, microarray: suitable, western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells.

isotype

IgG1

UniProt accession no.

P20073

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ANXA7(310)
mouse ... Anxa7(11750)
rat ... Anxa7(155423)

General description

Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.

Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.

Immunogen

recombinant mouse annexin VII.

Application

Anti-Annexin VII antibody, Mouse monoclonal has been used in:

western blotting
immunocytochemistry
immunohistochemistry

Biochem/physiol Actions

Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.

Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

046M4848

080M4854

022K4804

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Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model

Jin Y, et al.

BMC Cancer, 13(1), 522-522 (2013)

Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression

Leighton X, et al.

Testing, 13(10), e0205837-e0205837 (2018)

Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model.

Yanling Jin et al.

BMC cancer, 13, 522-522 (2013-11-06)

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model. The stable knockup and knockdown

SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.

ShuYan Liu et al.

Cancer letters, 416, 11-23 (2017-12-17)

Annexin A7 (ANXA7) is a suppressor of tumorigenesis and metastasis in prostate cancer. Activated ANXA7 GTPase promotes prostate cancer cell apoptosis. However, the role and underlying mechanism of ANXA7 GTPase in prostate cancer metastasis have not been established. RKIP is

Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts.

C S Clemen et al.

Journal of muscle research and cell motility, 20(7), 669-679 (2000-02-15)

Annexin VII exists in a 47 kDa and a 51 kDa isoform with the 51 kDa protein being the only isoform present in skeletal muscle. Expression of the 51 kDa isoform during myogenesis and localization was studied in cells after

Global Trade Item Number

SKU	GTIN
A4475-.2ML	04061838102249

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