A4730
Amthamine dihydrobromide
≥98% (HPLC), solid
Synonym(s):
2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C6H11N3S · 2HBr
CAS Number:
Molecular Weight:
319.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
Amthamine dihydrobromide, ≥98% (HPLC), solid
InChI key
XFXNNOPUDSFVJE-UHFFFAOYSA-N
SMILES string
Br[H].Br[H].Cc1nc(N)sc1CCN
InChI
1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
H2O: 27 mg/mL
storage temp.
2-8°C
Application
Amthamine dihydrobromide is a histamine H2 receptor agonist. Amthamine dihydrobromide has been used to study the effect of mast cells on T regulatory cell function.
Biochem/physiol Actions
Amthamine dihydrobromide is a H2 histamine receptor agonist. Amthamine dihydrobromide, similar to histamine, inhibits H2 receptor-mediated eosinophil peroxidase (EPO) release with IC50 = 0.4 μM; a weak antagonist at H3 and shows no activity at H1 receptors.
H2 histamine receptor agonist.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yi-Nan Chen et al.
Journal of neuroinflammation, 17(1), 217-217 (2020-07-24)
Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator of inflammation, can both promote and prevent microglia-related neuroinflammation by activating different
Wei Zhang et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 15(2), 280-291 (2019-12-22)
Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central nervous system. We have reported that histamine induces microglia activation and releases proinflammatory factors in primary cultured microglia. Whether histamine has similar effects in vivo is unknown.
Cardiac effects of amthamine: a new histamine H2-receptor agonist.
G Coruzzi et al.
European journal of clinical investigation, 25 Suppl 1, 27-28 (1995-03-01)
G Coruzzi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(1), 77-81 (1993-07-01)
The new histamine H2 receptor agonist amthamine, [2-amino-5-(2-aminoethyl)-4-methylthiazole], was tested for its activity on gastric acid secretion in different in vivo and in vitro experimental models. Amthamine induced a dose-related increase in acid secretion both in conscious cats with a
Yagna P R Jarajapu et al.
European journal of pharmacology, 547(1-3), 116-124 (2006-08-22)
The effect of histamine on the pressure-induced constriction was characterized in rat cerebral arteries and mechanisms were investigated. Rat cerebral arteries were pressurized to 70 mm Hg in an arteriograph and the effect of histamine on myogenic tone was studied.
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