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A4730

Amthamine dihydrobromide

≥98% (HPLC), solid

Synonym(s):

2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C6H11N3S · 2HBr
CAS Number:
142457-00-9
Molecular Weight:
319.06
NACRES:
NA.77
PubChem Substance ID:
24890905
UNSPSC Code:
12352200
MDL number:
MFCD00673891
Assay:
≥98% (HPLC)
Form:
solid
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assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: 27 mg/mL

storage temp.

2-8°C

SMILES string

Br[H].Br[H].Cc1nc(N)sc1CCN

InChI

1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H

InChI key

XFXNNOPUDSFVJE-UHFFFAOYSA-N

Application

Amthamine dihydrobromide is a histamine H2 receptor agonist. Amthamine dihydrobromide has been used to study the effect of mast cells on T regulatory cell function.

Biochem/physiol Actions

Amthamine dihydrobromide is a H2 histamine receptor agonist. Amthamine dihydrobromide, similar to histamine, inhibits H2 receptor-mediated eosinophil peroxidase (EPO) release with IC50 = 0.4 μM; a weak antagonist at H3 and shows no activity at H1 receptors.
H2 histamine receptor agonist.

Storage Class

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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