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Merck
CN

A5284

8-Azaguanine

Hybri-Max, γ-irradiated, powder, BioXtra, suitable for hybridoma

Synonym(s):

8-AzaG, 2-Amino-6-hydroxy-8-azapurine, 2-Amino-6-oxy-8-azapurine, Guanazolo

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About This Item

Empirical Formula (Hill Notation):
C4H4N6O
CAS Number:
Molecular Weight:
152.11
EC Number:
205-148-1
UNSPSC Code:
12352207
PubChem Substance ID:
Beilstein/REAXYS Number:
171098
MDL number:
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InChI

1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)

InChI key

LPXQRXLUHJKZIE-UHFFFAOYSA-N

SMILES string

NC1=Nc2[nH]nnc2C(=O)N1

grade

Hybri-Max

sterility

γ-irradiated

product line

BioXtra

form

powder

technique(s)

cell culture | hybridoma: suitable

mp

>300 °C (lit.)

storage temp.

−20°C

Application

For use in hybridoma cell culture applications as a myeloma selection agent.

Preparation Note

Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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July Fong et al.
Scientific reports, 8(1), 1155-1155 (2018-01-20)
The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence factors and formation of drug-resistant biofilms. Targeting
Qiao-Ling Gong et al.
Journal of molecular modeling, 18(2), 493-500 (2011-05-05)
The interaction between 8-azaguanine (8-Azan) and bovine serum albumin (BSA) in Tris-HCl buffer solutions at pH 7.4 was investigated by means of fluorescence and ultraviolet-visible (UV-Vis) spectroscopy. At 298 K and 310 K, at a wavelength of excitation (λ (ex))
Erwan Atcheson et al.
NPJ vaccines, 5, 92-92 (2020-10-22)
Malaria remains one of the world's most urgent global health problems, with almost half a million deaths and hundreds of millions of clinical cases each year. Existing interventions by themselves will not be enough to tackle infection in high-transmission areas.
Bashir Mir et al.
Nucleic acids research, 32(3), e25-e25 (2004-02-13)
The use of primary somatic cells in nuclear transfer procedure has opened a new opportunity to manipulate domestic animal genomes via homologous recombination. To date, while a few loci have been targeted in somatic cells using similar enrichment strategies as
Ziwei Li et al.
International journal of oncology, 52(6), 2079-2092 (2018-04-06)
Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes of death worldwide. Research investigating novel therapeutic strategies for the treatment of HCC is urgently required. Monoclonal antibodies (mAbs) that target the programmed cell death‑1 (PD‑1/PDCD1)/programmed death-ligand 1

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