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A5336

Asparaginase−polyethylene glycol from Escherichia coli

lyophilized powder, ~70 units/mg protein

Synonym(s):

PEG-Asparaginase

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About This Item

UNSPSC Code:
12352204
MDL number:
MFCD00676490
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form

lyophilized powder

specific activity

~70 units/mg protein

extent of labeling

≥40 mol PEG per mol protein

storage temp.

−20°C

Physical form

Contains PEG plus 5% citrate buffer salts

Preparation Note

Asparaginase coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
017K6104
066H8250

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A Abuchowski et al.
Cancer biochemistry biophysics, 7(2), 175-186 (1984-06-01)
The covalent attachment of monomethoxypolyethylene glycol (PEG) to asparaginases from Escherichia coli and Vibrio succinogenes by new coupling methodology produced conjugates that are active, stable, without significant immune response, and with greatly extended plasma half-lives in mice. Therapeutic efficacies were