A5626
Acetylthiocholine chloride
≥99% (TLC), powder
Synonym(s):
(2-Mercaptoethyl)trimethylammonium chloride acetate
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About This Item
Linear Formula:
CH3COSCH2CH2N(CH3)3Cl
CAS Number:
Molecular Weight:
197.73
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
Assay
≥99% (TLC)
form
powder
solubility
water: 100 mg/mL, clear to slightly hazy, colorless
storage temp.
−20°C
SMILES string
[Cl-].CC(=O)SCC[N+](C)(C)C
InChI
1S/C7H16NOS.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
GZYVLKKMMDFCKR-UHFFFAOYSA-M
Gene Information
human ... ACHE(43)
Application
Acetylthiocholine chloride has been used to determine the acetylcholine esterase activity of semen exosomes (SE). It has also been used as a substrate for acetylcholine esterase in microcalorimetric study of its kinetic parameters.
Biochem/physiol Actions
Acetylcholinesterase (AChE) enzyme plays an important physiological role in the neurotransmission process.
Acetylcholinesterase substrate and nicotinic acetylcholine receptor agonist.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Isolation of Exosomes from Semen for in vitro Uptake and HIV-1 Infection Assays
Madison MN, et al.
Bio-protocol, 7(7) (2017)
Jerneja Kladnik et al.
International journal of molecular sciences, 21(16) (2020-08-13)
The increasing number of Alzheimer's disease (AD) cases requires the development of new improved drug candidates, possessing the ability of more efficient treatment as well as less unwanted side effects. Cholinesterase enzymes are highly associated with the development of AD
Fouad H Darras et al.
Biochemical and biophysical research communications, 489(4), 451-454 (2017-06-03)
Defined as a state function representing an inhibitor's absolute affinity for its target enzyme, the experimentally determined enzyme inhibition constant (K
Muhammad Shakil Shah et al.
Computational biology and chemistry, 76, 310-317 (2018-08-25)
Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative disorders through restoration of acetylcholine (ACh) levels in the brain (e.g. Alzheimer's disease). To increase
Livia F Sgobbi et al.
Biosensors & bioelectronics, 100, 290-297 (2017-09-25)
A plethora of publications has continuously reported electrochemical biosensors for detection of pesticides. However, those devices rarely accomplish commercial application due to technical issues associated with the lack of stability and high cost of the biological recognition element (enzyme). Alternatively
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