A5737
Cefotetan disodium
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About This Item
Empirical Formula (Hill Notation):
C17H15N7Na2O8S4
CAS Number:
Molecular Weight:
619.58
UNSPSC Code:
51282206
NACRES:
NA.85
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
InChI
1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1
InChI key
ZQQALMSFFARWPK-GLHLDKNHSA-L
Biochem/physiol Actions
Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
涉药品监管产品
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Shaojun Shi et al.
Clinical therapeutics, 32(10), 1832-1841 (2011-01-05)
Cefotetan disodium for injection is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. Despite being widely used in the treatment of various infections, little information is available on the pharmacokinetic properties of cefotetan disodium
S Y Lee et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 13(5), 539-541 (2007-03-03)
This study evaluated the accuracy of cefotetan susceptibility determination using the MicroScan WalkAway system for AmpC-producing Klebsiella pneumoniae. In total, 57 K. pneumoniae isolates that showed a D-shape flattening in a double-disk synergy test were studied. Cefotetan MICs were determined
Drug-induced immune hemolytic anemia.
George Garratty
Clinical advances in hematology & oncology : H&O, 8(2), 98-101 (2010-04-14)
Samuel E Wilson et al.
Surgical infections, 9(3), 349-356 (2008-06-24)
The costs of treating surgical site infections can be considerable. There is a cost associated with the prophylactic use of antibiotics; however, the use of prophylactic agents may reduce infection rates and lengths of stay, thus offsetting the overall treatment
Najjia N Mahmoud et al.
Surgical infections, 10(6), 539-544 (2009-08-28)
Length of stay (LOS) and inpatient costs for open-abdomen colorectal procedures have not been examined recently. The aim of this study was to determine LOS and costs for several colorectal procedures in the context of factors potentially associated with surgical
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