A5737
Cefotetan disodium
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About This Item
Empirical Formula (Hill Notation):
C17H15N7Na2O8S4
CAS Number:
Molecular Weight:
619.58
UNSPSC Code:
51282206
NACRES:
NA.85
InChI
1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1
InChI key
ZQQALMSFFARWPK-GLHLDKNHSA-L
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Biochem/physiol Actions
Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Failure to administer cefotan: was standing order ambiguous? Tucker v. Women's Care Physicians of Louisville, CA-001929-mr(6/18/2010)-KY.
Nursing law's Regan report, 51(3), 2-2 (2010-11-26)
Ellie J C Goldstein et al.
Surgical infections, 10(2), 111-118 (2009-02-20)
A randomized study comparing single-dose cefotetan and ertapenem prophylaxis for elective colorectal surgery in 1,002 patients found ertapenem to be significantly more effective (p < 0.001). Failures of prophylaxis were thought to involve organisms resistant to both antimicrobial agents, isolated
Wookeun Lee et al.
The Korean journal of laboratory medicine, 29(5), 448-454 (2009-11-07)
Plasmid-mediated AmpC beta-lactamases (PABLs) have been detected in the strains of Escherichia coli, Klebsiella spp., Proteus mirabilis, and Salmonella spp. PABLs may be difficult to detect and might interfere in the therapeutic and infection-control processes. Although several PABL-detection methods based
Kamal M F Itani et al.
American journal of surgery, 193(2), 190-194 (2007-01-24)
The type of mechanical bowel preparation (MBP) used before elective colorectal surgery remains controversial. This post hoc analysis of a prospective randomized controlled antibiotic prophylaxis trial (ertapenem vs. cefotetan) evaluated the effect of polyethylene glycol (PEG) and sodium phosphate (SP)
Paul Suding et al.
Archives of surgery (Chicago, Ill. : 1960), 143(9), 907-911 (2008-09-17)
Anastomotic leaks following elective colorectal resections increase morbidity, mortality, and the need for additional interventions. An accurate understanding of risk factors would potentially reduce anastomotic leaks and/or allow appropriate selection of patients for diverting stomas. Prospective review of patient and
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