A5737
Cefotetan disodium
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About This Item
Empirical Formula (Hill Notation):
C17H15N7Na2O8S4
CAS Number:
Molecular Weight:
619.58
UNSPSC Code:
51282206
NACRES:
NA.85
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
InChI
1S/C17H17N7O8S4.2Na/c1-23-16(20-21-22-23)34-4-5-3-33-15-17(32-2,14(31)24(15)7(5)11(29)30)19-9(26)13-35-12(36-13)6(8(18)25)10(27)28;;/h13,15H,3-4H2,1-2H3,(H2,18,25)(H,19,26)(H,27,28)(H,29,30);;/q;2*+1/p-2/b12-6-;;/t13?,15-,17+;;/m1../s1
InChI key
ZQQALMSFFARWPK-GLHLDKNHSA-L
Biochem/physiol Actions
Cefotetan has good protein binding capacity due to its half-life of 3 to 4 hours. The presence of methylthiotetrazole (MTT) side chain helps to enhance its potential for hypoprothrombinemia and disulfiram reactions. It possesses high antimicrobial activity against gram-negative bacilli than cefoxitin.
Cefotetan (cefotan) is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria. Cefotetan binds to penicillin-binding proteins and disrupts the cell wall synthesis.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Drug-induced immune hemolytic anemia.
George Garratty
Clinical advances in hematology & oncology : H&O, 8(2), 98-101 (2010-04-14)
S Y Lee et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 13(5), 539-541 (2007-03-03)
This study evaluated the accuracy of cefotetan susceptibility determination using the MicroScan WalkAway system for AmpC-producing Klebsiella pneumoniae. In total, 57 K. pneumoniae isolates that showed a D-shape flattening in a double-disk synergy test were studied. Cefotetan MICs were determined
Shaojun Shi et al.
Clinical therapeutics, 32(10), 1832-1841 (2011-01-05)
Cefotetan disodium for injection is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. Despite being widely used in the treatment of various infections, little information is available on the pharmacokinetic properties of cefotetan disodium
Antibiotic prophylaxis in colorectal surgery.
Pierre Moine et al.
The New England journal of medicine, 356(16), 1684-1684 (2007-04-20)
James E Kendrick et al.
Journal of the American College of Surgeons, 207(3), 393-397 (2008-08-30)
To develop a standardized protocol for management of postoperative fever in gynecology patients to decrease unnecessary diagnostic workups and empiric use of antibiotics. A prospective analysis of postoperative gynecology patients identified those who experienced fever (maximum temperature [T(max)] > 100.4
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A5737-100MG | 04061833376263 |
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