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Merck
CN

A6345

Sigma-Aldrich

N-Acetyl-Ile-Glu-Pro-Asp-7-amino-4-trifluoromethylcoumarin

97% (HPLC), powder

Synonym(s):

Ac-IEPD-AFC

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About This Item

Linear Formula:
C32H38N5O11F3
Molecular Weight:
725.67
MDL number:
MFCD03452821
UNSPSC Code:
12352200
PubChem Substance ID:
329770891

Key Documents

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Assay

97% (HPLC)

form

powder

color

white

solubility

DMSO/DMF: 20 mM

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C32H38F3N5O11/c1-4-15(2)27(36-16(3)41)30(49)38-20(9-10-24(42)43)31(50)40-11-5-6-22(40)29(48)39-21(14-25(44)45)28(47)37-17-7-8-18-19(32(33,34)35)13-26(46)51-23(18)12-17/h7-8,12-13,15,20-22,27H,4-6,9-11,14H2,1-3H3,(H,36,41)(H,37,47)(H,38,49)(H,39,48)(H,42,43)(H,44,45)/t15-,20-,21-,22-,27-/m0/s1

InChI key

HWXKKVLJPWMVLL-FGGUPADCSA-N

Gene Information

human ... GZMB(3002)
mouse ... GZMB(171528)
rat ... GZMB(14939), RGD1561819(502004), RGD1562700(502007)

Amino Acid Sequence

NAc-Ile-Glu-Pro-Asp-AFC

Application

Fluorogenic substrate for granzyme B.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
100K0013

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J L Harris et al.
The Journal of biological chemistry, 273(42), 27364-27373 (1998-10-09)
Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes. Definition of the substrate specificity of granzyme B allows for the identification of in vivo substrates in this process. By using the combinatorial

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