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Merck
CN

A6351

A-315456

>98% (HPLC), solid

Synonym(s):

N-[3-(cyclohexylidene(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C18H23N3O2S
Molecular Weight:
345.46
UNSPSC Code:
12352200
PubChem Substance ID:
24278798
MDL number:
MFCD04040120

Key Documents

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InChI

1S/C18H23N3O2S/c1-2-24(22,23)21-16-10-6-9-15(11-16)18(17-12-19-13-20-17)14-7-4-3-5-8-14/h6,9-13,21H,2-5,7-8H2,1H3,(H,19,20)

SMILES string

CCS(=O)(=O)Nc1cccc(c1)C(=C2/CCCCC2)\c3cnc[nH]3

InChI key

MTZVJHSZYMWIAG-UHFFFAOYSA-N

assay

>98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble 24 mg/mL, H2O: insoluble

Gene Information

human ... ADRA1D(146)

Application

A-315456 is a potent and selective α1D-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the α(1D)-adrenoceptor subtype in normal and disease states.

Biochem/physiol Actions

Selective α1D-adrenoceptor antagonist.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
082K4701
072K4702

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S A Buckner et al.
European journal of pharmacology, 433(1), 123-127 (2002-01-05)
In functional assays, A-315456, N-[3-(cyclohexylidene-(1H-imidazol-4-ylmethyl))phenyl]ethanesulfonamide, behaved as an alpha(1D)-adrenoceptor subtype selective antagonist (pA(2)=8.34) in the rat aorta. It was 83-fold less potent at the alpha(1B)-adrenoceptor subtype expressed in the rat spleen, and was inactive at the alpha(1A)-adrenoceptor subtype expressed in

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