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Merck
CN

A6352

Anti-ADAMTS-2, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase with Thrombospondin-2 motif, Anti-Procollagen I N-Proteinase

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD04974663
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

O95450

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAMTS2(9509)

General description

ADAMTS-2 (or Procollagen I N-Proteinase, PNP) belongs to the ADAM (A Disintegrin And Metalloproteinase) family and has thrombospondin (TS) repeats. ADAMTS-2 has been implicated in collagen synthesis, angiogenesis and development. Alterations in this gene have been linked to Ehlers-Danlos syndrome type VII C, dermatosparaxis, and male infertility. Rabbit Anti-ADAMTS-2 binds to human ADAMTS-2.
By immunoblotting against the reduced protein, the antibody identifies the zymogen form at 130-140 kDa, activated forms at 94-105 kDa (major bands), and breakdown products at 50 kDa, 34 kDa in cell culture media and lysates.

Immunogen

synthetic peptide corresponding to the propeptide domain of the human ADAMTS-2.

Application

Rabbit Anti-ADAMTS-2 can be used for western blot applications at a dilution of 1:1,000.

Physical form

Solution in phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
033K1420

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A Colige et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2374-2379 (1997-03-18)
Procollagen N-proteinase (EC 3.4.24.14) cleaves the amino-propeptides in the processing of type I and type II procollagens to collagens. Deficiencies of the enzyme cause dermatosparaxis in cattle and sheep, and they cause type VIIC Ehlers-Danlos syndrome in humans, heritable disorders
B L Tang
The international journal of biochemistry & cell biology, 33(1), 33-44 (2001-02-13)
ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (a disintegrin and metalloprotease) family members based on the

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