A6397
Antithrombin III from rat plasma
lyophilized powder, >200 units/mg protein (E1%/280 = 6.5)
Synonym(s):
Factor Xa inhibitor, Heparin cofactor
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About This Item
form
lyophilized powder
specific activity
>200 units/mg protein (E1%/280 = 6.5)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
rat ... Serpinc1(304917)
Biochem/physiol Actions
Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase.
Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase. AT III becomes depleted in sepsis, toxic shock, severe burns, organ failure, and xenotransplantation. AT III supplementation reduces morbidity and mortality in animal models of sepsis and organ failure.
Preparation Note
When reconstituted with 1.0 ml of deionized water, solution will contain a minimum of the stated activity in 0.1 M sodium chloride, and 0.02 M Tris, pH 7.5.
Analysis Note
Homogeneous by gel electrophoresis.
Other Notes
Not to be confused with thrombin antiserum.
One unit is the activity present in 0.1 ml of normal human pooled plasma tested in the presence of 0.1 unit of heparin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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G Dickneite
Seminars in thrombosis and hemostasis, 24(1), 61-69 (1998-03-27)
Antithrombin III (AT III) is the physiological inhibitor of thrombin and other serine proteases of the clotting cascade. In the development of sepsis, septic shock and organ failure, the plasma levels of AT III decrease considerably, suggesting the concept of
Courtney E Coombes et al.
Current biology : CB, 30(4), 610-623 (2020-01-14)
Neuronal axons terminate as synaptic boutons that form stable yet plastic connections with their targets. Synaptic bouton development relies on an underlying network of both long-lived and dynamic microtubules that provide structural stability for the boutons while also allowing for
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