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A6605

AMN082

Name: AMN082
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₈N₂ · 2HCl

CAS Number:

97075-46-2

Molecular Weight:

465.46

UNSPSC Code:

12352200

PubChem Substance ID:

24891112

MDL number:

MFCD08702723

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assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥5 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].C(CNC(c1ccccc1)c2ccccc2)NC(c3ccccc3)c4ccccc4

InChI

1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H

InChI key

YRQCDCNQANSUPB-UHFFFAOYSA-N

Application

AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.

Biochem/physiol Actions

AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC₅₀ = 64 nM) and stimulates GTPγS binding (EC₅₀ = 290 nM) similar to L-AP₄ and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.

AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 stimulates the release of stress hormones (corticosterone and ACTH), orally active and brain penetrable.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia.

Joanna M Wierońska et al.

Psychopharmacology, 220(3), 481-494 (2011-09-29)

Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. Here, we decided to investigate the possible role of the group III mGlu receptor

Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.

Katharina Gryksa et al.

Genes, brain, and behavior, 19(1), e12627-e12627 (2019-12-04)

The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate

Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain.

Tomoteru Yamasaki et al.

EJNMMI research, 3(1), 54-54 (2013-07-23)

Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant KB = 30 nM), and evaluated

Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2.

Katarzyna Stachowicz et al.

Neuroscience letters, 741, 135435-135435 (2020-11-11)

Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus

The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice.

Karolina Podkowa et al.

Neuropharmacology, 141, 214-222 (2018-08-27)

Scopolamine, a muscarinic cholinergic receptor antagonist, exerts fast and prolonged antidepressant effects in the clinic. In contrast, the current treatments for major depressive disorder (MDD) require long-term drug administration. On the other hand, the sole use of scopolamine might be

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