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About This Item
Empirical Formula (Hill Notation):
C2936H4624N786O889S41
CAS Number:
Molecular Weight:
66471.53
NACRES:
NA.25
UNSPSC Code:
12352202
EC Number:
274-272-6
MDL number:
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
biological source
human
recombinant
expressed in rice
assay
≥99% (PAGE)
form
lyophilized powder
mol wt
monomer ~67 kDa
composition
Protein, ≥90% biuret
technique(s)
cell culture | mammalian: suitable
impurities
≤6.7 EU/g Endotoxin
pH range
6.5-7.2
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... ALB(213)
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General description
Human serum albumin (HSA) is encoded by the gene mapped to human chromosome 4. Albumin is a globular protein with 585 amino acids. It is the most prominent protein in human sera. Albumin constitutes total concentration of about 60% of the total proteins in the blood serum. The encoded protein contains three globular domains that resemble each other in structure, each containing two subdomains. Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds.
Application
This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.
Biochem/physiol Actions
Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.
Serum albumin functions as a carrier protein for steroids, fatty acids and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood. This globular protein is broadly used to treat serious burn injuries, hemorrhagic shock, hypoproteinemia, fetal erythroblastosis and ascites caused by liver cirrhosis. HSA has various biological applications, such as carrier of oxygen, nanodelivery of drugs and fusion of peptides.
Other Notes
View more information on human serum albumin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Large-scale production of functional human serum albumin from transgenic rice seeds.
He Y, et al.
Proceedings of the National Academy of Sciences of the USA, 201109736-201109736 (2011)
Hung X Nguyen et al.
Nature communications, 13(1), 620-620 (2022-02-04)
Therapies for cardiac arrhythmias could greatly benefit from approaches to enhance electrical excitability and action potential conduction in the heart by stably overexpressing mammalian voltage-gated sodium channels. However, the large size of these channels precludes their incorporation into therapeutic viral
Ilya Y Shadrin et al.
Nature communications, 8(1), 1825-1825 (2017-12-01)
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a "Cardiopatch" platform for 3D culture and
The three recombinant domains of human serum albumin structural characterization and ligand binding properties.
Dockal M, et al.
The Journal of Biological Chemistry, 274(41), 29303-29310 (1999)
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