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Merck
CN

A6727

Anti-ADAMTS-5, C-Terminal antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-A Disintegrin And Metalloproteinase with ThromboSpondin-5 motif, Anti-Aggrecanase-2, Anti-Implantin

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD04974667
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:1,000

UniProt accession no.

Q9UNA0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADAMTS5(11096)

General description

ADAMT5 is a member of the family of ADAMTs proteins that contain 3 specific domains: MMP, disintegrin, and a thrombospondin type-1 domain. ADAMT5 is highly expressed in cartilage.
By immunoblotting against the reduced protein, the antibody identifies the zymogen form at 120 kDa, activated form at 73 kDa (major band), and breakdown products at 50 kDa and 40 kDa in cell lysates.
Rabbit Anti-ADAMTS-5, C-terminal antibody binds to the C-terminus of human ADAMTS-5.

Immunogen

synthetic peptide corresponding to the C-terminus of human ADAMTS-5.

Application

Rabbit Anti-ADAMTS-5, C-Terminal antibody can be used for western blot applications at a dilution of 1:1,000.

Physical form

Solution in phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
086K1559
085K1842
055K1399
033K1554

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ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.
Hurskainen, T
Journal of Biochemistry, 274, 25555-25563 (1999)
Q Zhang et al.
Osteoarthritis and cartilage, 23(12), 2259-2268 (2015-07-15)
To identify whether cartilage master regulator SRY-related protein 9 (SOX9) mediates A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) dysregulation during osteoarthritis (OA) cartilage degeneration. Twenty-two randomly selected OA patients were evaluated using Outerbridge Classification via arthroscopy. Haematoxylin-eosin (HE), Safranin

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