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Merck
CN

A6882

Atractyloside potassium salt

≥98% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C30H44K2O16S2
CAS Number:
102130-43-8
Molecular Weight:
802.99
UNSPSC Code:
12352200
PubChem Substance ID:
24891150
MDL number:
MFCD00078810

Key Documents

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SMILES string

[K+].[K+].[H][C@@]12CC[C@@]3([H])[C@]4(C)C[C@@H](C[C@@H](C(O)=O)[C@@]4([H])CC[C@]3(C1)[C@@H](O)C2=C)O[C@@H]5O[C@H](CO)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]5OC(=O)CC(C)C

assay

≥98% (TLC)

solubility

H2O: 20 mg/mL

Biochem/physiol Actions

An extremely toxic glycoside isolated from thistles. Inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane.
Extremely toxic thistle glycoside. Inhibits oxidative phosphorylation; blocks transfer of adenosine nucleotides through the mitochondrial membrane.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
029H06461
094F0383
029H0646

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Sebastian A Barrientos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(3), 966-978 (2011-01-21)
Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can cause permanent loss of function, so it represents a focus for neuroprotective strategies.
Rashel Mizrahi et al.
Biochimica et biophysica acta, 1840(12), 3404-3412 (2014-09-16)
Mitochondria are the major source of ATP to power sperm motility. Phosphorylation of mitochondrial proteins has been proposed as a major regulatory mechanism for mitochondrial bioenergetics. Sperm motility was measured by a computer-assisted analyzer, protein detection by western blotting, membrane

Related Content

Product Information Sheet - A6882

Product Information Sheet

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